Arterial Perfusion
Arterial Perfusion - Related Videos
12:29
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Cited by 18 •
2011
A MR imaging method to study the distribution of pulmonary blood flow under a variety of physiological conditions, in this case exposure to three different inspired oxygen concentrations: hypoxia, normoxia, and hyperoxia, is described. This technique utilizes human pulmonary physiology research techniques in an MR scanning environment.
12:15
Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
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Cited by 8 •
2013
Cerebral perfusion monitoring has been demonstrated to improve accuracy in ischemic stroke models. Technical difficulties often limit the use of this essential tool for cerebrovascular research. In this video, an optimized system is shown to obtain a single or multi-site hemodynamic monitoring during intraluminal middle cerebral artery occlusion in rats.
04:44
Antegrade Perfusion Model: An Ex Vivo Technique to Perfuse Isolated Mouse Heart
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2025
This video describes an antegrade perfusion technique of an isolated mouse heart during which a perfusate is injected through the left ventricle, and eventually, it perfuses the entire myocardium. This method can be used to isolate cardiomyocytes from murine models and generate decellularized hearts for further downstream applications.
03:44
Langendorff Retrograde Heart Perfusion: An Ex Vivo Technique to Perfuse Isolated Mouse Heart
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2025
In this video, we perform Langendorff retrograde perfusion of an isolated mouse heart. During the procedure, the cardiac activity of the heart is maintained by perfusing it retrogradely with a perfusion solution via the coronary arteries using a cannula inserted into the ascending aorta. The model is used to study the cardiac pathophysiology of the heart.
07:32
Porcine Normothermic Isolated Liver Perfusion
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Cited by 3 •
2023
The porcine model of liver normothermic machine perfusion (NMP), described here, can be successfully used to study NMP as a preservation strategy, a tool for viability assessment, and a platform for organ repair. It holds a high translational value, however it is technically challenging and labor-intensive.
FAQs
The balance among cardiac output, arterial pressure, and vascular resistance determines how effectively blood reaches tissues. Pressure gradients provide the driving force, while changes in vascular resistance can redirect flow. Reduced cardiac output or arterial pressure can limit delivery, whereas increased resistance from vasoconstriction can restrict distribution. These relationships explain why cardiovascular status directly affects tissue viability.
Local autoregulation adjusts arterial flow to match changing tissue demands rather than distributing blood uniformly. Vasoconstriction can reduce flow to a region, while vasodilation can increase it when demand rises. This local control complements systemic influences such as cardiac output and arterial pressure, helping preserve organ function when overall circulatory conditions change.
Insufficient delivery reduces access to oxygenated blood needed for tissue metabolism and organ function. If flow becomes inadequate, the resulting mismatch between tissue demand and supply may present clinically as ischemia. This concern is especially important in shock, peripheral vascular disease, trauma, and surgery, where clinicians must determine whether affected tissues remain viable.
Pulse quality, skin temperature, and capillary refill provide bedside clues about the adequacy of arterial blood flow. Clinicians can interpret these findings together and consider whether the pattern suggests compromised perfusion. This practical assessment supports recognition of ischemia, shock, or peripheral vascular disease and can prompt further evaluation when tissue blood supply appears inadequate.
Imaging-based blood-flow measurements provide an additional way to evaluate circulation when clinical assessment requires more information. They help characterize blood movement through arterial pathways and support evaluation of suspected ischemia or peripheral vascular disease. In surgical or trauma settings, these measurements may also help determine whether tissue receives enough flow to remain viable.
Assessment findings connect the state of circulation with the condition of tissues and help guide management. Evidence of compromised delivery can direct attention to fluid and cardiovascular management, while the findings also help evaluate whether tissue remains viable. During surgery, trauma, or critical illness, this information supports timely decisions when ischemia or shock is suspected.