Birth Asphyxia
Birth Asphyxia - Related Videos
10:36
A Swine Model of Neonatal Asphyxia
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Cited by 50 •
2011
Large animal models have good translational values in the examination of physiology and pharmacology of neonatal asphyxia. Using newborn piglets, we develop an experimental protocol to simulate neonatal asphyxia which has advantages of studying the systemic and regional hemodynamics, oxygen transport with biochemical and pathologic pathways and correlations.
14:43
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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Cited by 40 •
2018
This manuscript describes the Research Prioritization by Affected Communities (RPAC) protocol and findings from its use with women at risk for preterm birth. Using the protocol, women identified and prioritized their unanswered questions about pregnancy, birth and neonatal care aimed at influencing research priority setting by funders and researchers.
01:22
Birth Control Methods
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2024
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
09:42
Development of a Neonatal Rat Model for Brachial Plexus Birth Injury
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2026
This protocol presents a step-by-step instruction to create a neonatal brachial plexus injury in rats to be used as a model in brachial plexus birth injury research.
04:18
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
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2025
Preterm birth (delivery < 37 weeks) is an urgent global health issue with suboptimal prevention and treatment options. We present a mouse model of ascending vaginal bacterial infection-induced preterm birth and outline how to analyze the resulting neonatal morbidity and mortality.
FAQs
The central problem is failing gas exchange: oxygen delivery falls while carbon dioxide removal is reduced. This combination can produce hypoxemia, meaning low oxygen in the blood, and hypercapnia, meaning elevated carbon dioxide. Continued disturbance may also cause metabolic acidosis, an acid-base imbalance that signals broader physiologic stress and helps explain why prompt clinical attention is necessary.
Brain tissue is especially important because inadequate cerebral oxygenation can disrupt neurologic function and lead to hypoxic-ischemic encephalopathy. This condition represents brain injury associated with the oxygen deficit. Recognizing these neurologic consequences matters beyond the delivery room: neurologic status helps guide immediate decisions, while later follow-up can inform developmental care.
Blood gases provide physiologic information that complements observations of breathing, circulation, and neurologic status. Clinicians can use them to identify the pattern of hypoxemia, hypercapnia, and metabolic acidosis associated with impaired gas exchange. Considering these findings together supports decisions about immediate neonatal resuscitation and the need for ongoing monitoring.
Because oxygen delivery supports multiple organs, the consequences are not confined to the brain. Birth asphyxia can injure the brain and other organs, so assessment must extend beyond neurologic findings. Reviewing breathing and circulation together with blood-gas results gives clinicians a broader picture of the newborn’s condition and helps direct immediate care.
Initial evaluation combines several domains rather than relying on a single sign. Clinicians assess breathing and circulation, review blood gases, and examine neurologic status. This integrated assessment helps determine how urgently the newborn needs resuscitation, whether assisted ventilation is required, and how closely the infant should be monitored afterward.
Assisted ventilation addresses inadequate gas exchange during immediate neonatal resuscitation by supporting oxygen delivery and carbon dioxide removal. Its use is guided by the newborn’s breathing, circulation, blood-gas findings, and neurologic status. The objective is to respond promptly to physiologic compromise and limit the duration of oxygen deprivation that can contribute to organ injury.
Therapeutic hypothermia is used for selected infants after clinical assessment rather than as a universal intervention. In that context, cooling is an early treatment intended to improve the chances of limiting injury, particularly when inadequate cerebral oxygenation raises concern for hypoxic-ischemic encephalopathy. The newborn’s evaluation determines whether this approach is appropriate.
Initial stabilization does not end the clinical significance of the event. Monitoring helps clinicians follow the newborn after immediate resuscitation and gather information relevant to later care. Neurologic status remains important because hypoxic-ischemic encephalopathy can affect the brain, while possible injury to other organs supports broader observation and long-term developmental care.