Cardiac Morphology

Cardiac morphology is the study of the heart’s form, structure, and spatial relationships, providing a foundation for understanding normal function and disease. It examines chambers, valves, myocardium, coronary vessels, and conduction-related anatomy through methods such as dissection, echocardiography, computed tomography, and magnetic resonance imaging; these approaches reveal how wall thickness, chamber geometry, and blood-flow pathways relate to cardiac performance. In medicine, morphological assessment supports recognition of congenital heart defects, cardiomyopathies, valvular disease, and structural changes associated with aging or hypertension. Linking anatomy with physiology also guides diagnosis, risk assessment, surgical planning, and development of patient-specific treatments.

Cardiac Morphology - Related Videos

Research

JoVE Journal - Medicine

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

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Cited by 29 •

2017

Echocardiographic examination is frequently used in mice. Expensive high-resolution ultrasound devices have been developed for this purpose. This protocol describes an affordable echocardiographic procedure combined with histological morphometric analyses to determine cardiac morphology.

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

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Cited by 2 •

2013

Contrast enhanced cardiac magnetic resonance (CMR) imaging allows comprehensive in vivo assessment of the heart in small animal models of cardiovascular disease. Here we detail the procedures to perform CMR imaging, reconstruction and analysis using Small Animal Lock-Locker Inversion Recovery (SALLI) in rats.

Mouse Echocardiography: A Non-invasive Technique to Assess Cardiac Morphology

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2023

This video describes a protocol to perform echocardiography on a laboratory mouse.

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

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Cited by 25 •

2016

The goal of this protocol is to noninvasively assess cardiac structural and functional changes in a mouse model of heart disease created by transverse aortic constriction, using B- and M-mode echocardiography and color/pulse wave Doppler imaging.

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

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Cited by 11 •

2015

Streptococcus pneumoniae forms discrete non-purulent microscopic lesions in the heart. Outlined is the protocol for a murine model of cardiac microlesion formation. Instruction is provided on microlesion visualization using microscopy, discrimination between early and late microlesions, and methods to detect cardiac remodeling in hearts of convalescent animals.

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