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01:33
Blood Collection in a Pig Model
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Blood collection is a common procedure in swine research and clinical studies. The choice of sampling site depends on the animal's age, body size, the volume of blood required, the study objectives and approved IACUC...
08:29
Basic Mouse Care and Maintenance
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2023
Mice (Mus musculus) are small rodents that breed and sexually mature quickly, making them perfectly suited to generating large animal colonies for biological research. As compared to other mammalian species, mice are simple and inexpensive to maintain in the laboratory. Nevertheless, mouse colonies do have specific husbandry needs that are critical to preserving animal health and safety as well as experimental reproducibility. This video demonstrates standard practices that ensure mice are...
06:42
Murine Skin Transplantation
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Cited by 35 •
2008
Allogeneic skin transplantation is a standard model to assay host T cell responses to MHC-disparate donor antigens. This video-article provides a visual tutorial of each step involved in performing a BALB/c-->C57BL/6 skin transplant.
04:36
Adenocarcinoma Engraftment: A Method to Implant Cancer Cells into the Murine Lungs
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2023
This video describes a method to engraft lung adenocarcinoma cells in murine lungs by preconditioning the airways with fibrosis-inducing agent–bleomycin. This method significantly enhances orthotopic engraftment of lung cancer cells into murine...
05:24
Unilateral Gonadectomy in Adult Male Xenopus laevis
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2026
We present a protocol for the surgical removal of one testis from adult male X. laevis, which allows the use of the second testis at a later time. This protocol aims to reduce the number of male frogs required for in vitro fertilization.
FAQs
IACUCs weigh expected scientific value against animal burden rather than approving use solely because a study addresses an interesting question. Reviewers examine the proposed species and number, housing and handling, possible pain or distress, humane endpoints, and investigator training. This process connects ethical acceptability to a scientifically defensible rationale and practical safeguards for the animals.
Replacement, reduction, and refinement guide different choices during study design. Together, these principles encourage investigators to question whether live vertebrate animals are needed, justify the number proposed, and improve housing, handling, or other procedures to reduce pain and distress. Applying them early helps preserve the study’s scientific purpose while limiting animal harm.
Initial review establishes whether the proposed procedures, safeguards, and scientific rationale are acceptable before work begins. Ongoing monitoring extends that oversight throughout the study by keeping attention on animal welfare, including pain, distress, handling, and humane endpoints. This continuing role helps ensure that ethical protections remain relevant as the approved research proceeds.
The protocol must provide a basis for evaluating the species and number of animals, housing and handling procedures, potential pain or distress, humane endpoints, and investigator training. These elements allow the committee to judge both welfare protections and scientific justification before the study starts. They also make the planned animal use assessable rather than implicit.
Psychology studies of learning, memory, behavior, and cognition may depend on observing how animals respond under carefully defined conditions. IACUC review requires the expected scientific value of those studies to justify animal use and encourages procedures that minimize harm. Oversight therefore connects behavioral research goals with responsible treatment of the animals producing the observations.
The review evaluates safeguards built into the research plan, including appropriate housing and handling, attention to possible pain or distress, humane endpoints, and investigator training. It also considers whether the proposed species and number are warranted. Together, these checks support ethical, scientifically justified studies and provide a basis for continued welfare monitoring during the work.