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Genome-wide Kartlegging av narkotika DNA Interactions i Cells med COSMIC (Fornetting av små molekyler å isolere Chromatin)
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Genome-wide Kartlegging av narkotika DNA Interactions i Cells med COSMIC (Fornetting av små molekyler å isolere Chromatin)

Article DOI: 10.3791/53510-v • 10:05 min • January 20th, 2016
January 20th, 2016 •
1, 1, 1,2, 3, 1, 1,4
1Department of Biochemistry, University of Wisconsin–Madison, 2Department of Electrical and Computer Engineering, University of Wisconsin–Madison, 3Graduate Program in Cellular and Molecular Biology, University of Wisconsin–Madison, 4The Genome Center, University of Wisconsin–Madison

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Identifisere de direkte målene for genom målretting molekyler er fortsatt en stor utfordring. For å forstå hvordan DNA-bindende molekyler engasjere genomet, har vi utviklet en metode som er avhengig av kryssbinding av små molekyler å isolere kromatin (COSMIC).

Tags

Molecular Biology COSMIC CSI molekylær anerkjennelse cheminformatics kjemiske genomikk polyamid genom målretting presisjon medisin DNA kromatin immunopresipitering neste generasjons sekvense
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