Name: how gene families evolve and diversify
Uploaded: 2020-11-23T11:47:33.000Z
Duration: 1 min 57 s
Channel: JoVE

K12 Standards

north-carolina-k-12-science-standard-course-of-study

North Carolina K-12 Science Standard Course of Study

9-12

Biology

Biological Evolution- Unity and Diversity

LS.Bio.9.2

Gene Families

Como las células se dividen con frecuencia, también deben duplicar sus genomas con frecuencia. Durante este proceso, pueden ocurrir errores que conducen a la duplicación de regiones de ADN. 
Si una sección duplicada de ADN contiene una o más regiones codificantes, esto se conoce como duplicación de genes. Liberada de las restricciones impuestas al gen original para mantener la función, la copia del gen ahora puede adquirir mutaciones y puede evolucionar para cumplir una nueva función dentro de la célula. Nos referimos a los genes que han evolucionado de esta manera, a través de la duplicación de genes existentes en el genoma de una sola especie, como "parálogos". 
Ortólogos, por otro lado, es un término utilizado para describir genes en diferentes especies que surgieron de un ancestro común pero continuaron evolucionando después de uno o más eventos de especiación. 
El término "homólogo" puede aplicarse en ambos casos, y simplemente describe genes con un ancestro común. Los grupos de genes homólogos se denominan colectivamente "familias de genes".
Debido a su ADN relacionado y a las similitudes de proteínas resultantes, los genes dentro de una familia de genes suelen producir proteínas que realizan funciones similares. 
Por ejemplo, la hemoglobina y la mioglobina son proteínas relacionadas que realizan la unión de oxígeno en los mamíferos. Sin embargo, la hemoglobina ha evolucionado como una molécula principal de transporte de oxígeno, mientras que el papel de la mioglobina está en el almacenamiento de oxígeno.
Al examinar las secuencias del genoma, estas familias de genes a menudo se pueden identificar y clasificar debido a su alta similitud de secuencia. 
Además, el estudio de las familias de genes puede ayudar a plantear hipótesis sobre la función de un gen recién descubierto, incluso en ausencia de una proteína.

<ol>
	<li>1ID de PDB: 1GZX 
	Paoli, M., Liddington, R., Tame, J., Wilkinson, A., Dodson, G. (1996) Estructura cristalina de la hemoglobina en estado T con oxígeno unido a los cuatro hemas. J Mol Biol 256: 775</li>
	<li>2ID de PDB: 3RGK 
	Hubbard, S.R., Lambright, S.G., Boxer, S.G., Hendrickson, W.A. (1990) Estructura cristalina de rayos X de un mutante de mioglobina humana recombinante a una resolución de 2,8 A. J Mol Biol 20: 215-218 DOI: 10.1016/S0022-2836(05)80181-0</li>
	<li>H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne. (2000) Investigación de ácidos nucleicos del banco de datos de proteínas, 28: 235-242</li>
	<li>D. Sehnal, A.S. Rose, J. Kovca, S.K. Burley, S. Velankar (2018) Mol*: Towards a common library and tools for web molecular graphics MolVA/EuroVis Proceedings. doi:10.2312/molva.20181103</li>
	<li>S. Cheng, J. Ashley, J. D Kurleto, M.Lobb-Rabe, Y.J. Park, R.A. Carrillo, E. Özkan (2019). Bases moleculares de la especificidad sináptica por receptores de la superfamilia de inmunoglobulinas en Drosophila. eLife 2019; 8:e41028 DOI: 10.7554/eLife.41028</li>
</ol>

familias de genes

Las familias de genes consisten en grupos de genes que se supone se originaron a partir de un ancestro común. Por lo general, surgen a través de eventos en los que un gen o genes se duplican por error durante la división celular. A diferencia de sus genes originales (que están sujetos a presión de selección para mantener su función), estas copias de genes no necesitan preservar sus secuencias y pueden evolucionar a un ritmo relativamente más rápido.

En ocasiones, estas regiones pueden adaptarse para asumir nuevas funciones dentro del organismo, convirtiéndose en genes novedosos por derecho propio. Cuando esto ocurre, nos referimos a estos genes como parálogos: dos genes dentro de la misma especie que evolucionaron a partir de un gen ancestral común.

Otro término común cuando se hace referencia a miembros de una familia de genes es ortólogo. Los genes ortólogos son aquellos que surgieron de un gen ancestral común pero continuaron evolucionando después de uno o más eventos de especiación. Por ejemplo, el gen de la enzima trehalasa de ratón tendría un ortólogo en humanos que también produce la enzima trehalasa. Sin embargo, estos genes y sus productos serían, al menos, parcialmente diferentes en secuencia debido a los años de cambios evolutivos desde el último ancestro común del ratón y el ser humano. Por tanto, son ortólogos de la misma familia de genes.

El tercer término común utilizado dentro de las familias de genes es genes homólogos. Este término es más amplio y se aplica a todos los genes relacionados dentro de una familia de genes.

Además, el término superfamilia se utiliza a veces para referirse a grupos muy grandes de genes y proteínas que muestran suficiente homología como para tener un ancestro común compartido. Para estas familias numerosas, la agrupación puede depender de similitudes mecanísticas para determinar el alcance del grupo. Como consecuencia de su origen genético compartido, los genes dentro de una familia de genes suelen realizar funciones relacionadas. La superfamilia de las inmunoglobulinas, por ejemplo, comprende una gran cantidad de genes que codifican proteínas tanto solubles como de la superficie celular implicadas en respuestas inmunológicas como la unión o adhesión celular. La característica clave de esta familia es que los miembros comparten un dominio común llamado pliegue de inmunoglobulina, que es fundamentalmente crítica para su función.

Familias de genes

Las familias de genes consisten en grupos de genes que se propone que se originaron a partir de un ancestro común. Por lo general, estos surgen a través de eventos en los que un gen o genes ...

Education

Educación

JoVE Core

Molecular Biology

Biología Molecular

Unit 1

Unidad 1

DNA, Cells, and Evolution

ADN, células y evolución

KEY TERMS AND CONCEPTS

TÉRMINOS Y CONCEPTOS CLAVE

how gene families evolve and diversify

Gene families are groups of genes that are thought to come from a shared ancestor. They usually form when a gene is copied by mistake during cell division. The original gene stays under selection pressure to keep its job, while the extra copy can change more quickly over time.

Some copied genes gain a new role in the organism. When that happens, they are called paralogs, which are two genes in the same species that evolved from one common ancestral gene. Gene families also include orthologs, which are genes in different species that came from the same ancestral gene and kept evolving after speciation, or the split of one species into separate species.

A mouse trehalase gene, for example, has an ortholog in humans that also makes the trehalase enzyme. Even so, the mouse and human genes, and the proteins they produce, are not identical. They differ at least partly in sequence because of the time since mouse and human shared a common ancestor.

The term homologous genes is broader. It includes all related genes in a gene family. The term superfamily is sometimes used for very large groups of genes and proteins with enough homology, or shared ancestry, to be grouped together. For these large groups, scientists may also use shared mechanism as part of the classification.

Genes in the same family usually do related jobs. One example is the immunoglobulin superfamily. It includes many genes that code for soluble proteins and cell surface proteins involved in immune responses such as cell binding and adhesion. A key feature of this family is a shared domain called the immunoglobulin fold, which is important for function.

How Gene Families Evolve and Diversify

the dna helix

DNA Structure and Base Pairing

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the central dogma

DNA to Protein: Central Dogma Steps

The central dogma explains how genetic information moves from DNA to RNA to protein. This flow is a key idea in molecular biology. It helps show how cells use genes to make the molecules that carry out work. DNA stores the instructions for making proteins. During transcription, a gene in DNA is copied into RNA. The RNA then carries that message to the next stage. In translation, the RNA message is used to build a protein. Proteins do much of the cell’s work, so this process connects genes to...

prokaryotic cells

Inside Prokaryotic Cell Structure

Prokaryotic cells have a simple internal structure compared with many other cells. They are usually divided into two groups: bacteria and archaea. These cells have no nucleus, so their DNA is not enclosed in a membrane-bound compartment. Instead, the genetic material is found in the nucleoid, a region where the DNA is located in the cell. Some prokaryotic cells also contain plasmids, which are small extra DNA molecules. A capsule may surround the cell and provide an additional outer layer. <br...

eukaryotic compartmentalization

Cell Compartments in Eukaryotes

Eukaryotic cells use compartments to organize many different jobs inside one cell. These compartments help separate processes so they can happen in the right place. The compartment called the cytosol is the fluid part of the cell. It surrounds the other internal structures and helps support many cell processes. Inside the cell, membrane-bound organelles create distinct microenvironments. A microenvironment is a small internal space with conditions that fit a specific task. This separation...

the tree of life - bacteria, archaea, eukaryotes

the-tree-of-life-bacteria-archaea-eukaryotes

How Life Is Classified Into Three Domains

The tree of life shows how organisms are related through evolution. Its root represents the common ancestor of all life on Earth. From that point, branches spread out like a tree. The tips of the branches represent living, or extant, species. Species that no longer exist, called extinct species, appear closer to the center of the tree. Today, these organisms are grouped into three domains: bacteria, archaea, and eukaryotes. Scientists still debate these divisions, so the tree of life keeps...

mutations

How Mutations Change DNA

Mutations are changes in DNA. They can alter the genetic code and affect how genes work. In high school biology, students often study mutations to understand how DNA changes can influence traits. The transcript focuses on two common mutation types: point mutations and frameshift mutations. A point mutation changes one nucleotide, which is one DNA building block. A frameshift mutation happens when nucleotides are added or removed and the reading frame shifts. These changes matter because they...

gene evolution - fast or slow?

Why Some Gene Regions Evolve Faster

Gene regions do not all change at the same rate. In eukaryotes, long stretches of DNA do not code for proteins or RNAs. Some of these non-coding regions include important regulatory sequences, but most have no known function. Because little or no selection pressure acts on them, they often change the fastest over evolutionary time. Protein-coding regions usually evolve more slowly. A change in a coding sequence can alter a protein and make it less effective at doing its job. That creates...

genome size and the evolution of new genes

genome-size-and-the-evolution-of-new-genes

How Genome Size Shapes New Genes

Genome size can vary widely, and it also helps show how new genes form. Every living organism has a genome, whether it uses RNA or DNA. Yet the size of that genome can be very different from one organism to another. One major difference is whether the organism is prokaryotic or eukaryotic. Prokaryotic genomes usually have little to no non-coding sequence, which means genes are packed closely together in operons along the chromosome. Eukaryotic genomes contain long stretches of non-coding DNA...

gene families

Gene families are groups of genes that are thought to come from a shared ancestor. They usually form when a gene is copied by mistake during cell division. The original gene stays under selection pressure to keep its job, while the extra copy can change more quickly over time. Some copied genes gain a new role in the organism. When that happens, they are called paralogs, which are two genes in the same species that evolved from one common ancestral gene. Gene families also include orthologs,...

types of genetic transfer between organisms

types-of-genetic-transfer-between-organisms

How Genes Move Within and Across Generations

Genetic transfer is the movement of genetic information from one organism to another. It happens in two main ways: vertical gene transfer and horizontal gene transfer. Vertical gene transfer moves genes from one generation to the next. It is much more common than horizontal gene transfer. Vertical gene transfer happens during both sexual reproduction and asexual reproduction. In both cases, one or more organisms pass some or all of their genome to their offspring. This kind of transfer occurs...

key terms and concepts

Learn how gene families form from duplicated genes, and how paralogs, orthologs, and homologous genes are related in evolution and function.

How Gene Families Evolve and Diversify | JoVE K12

molecular biology

JoVE Core Biología Molecular presenta los procesos moleculares de la célula a través de lecciones claras y concisas de animaciones audiovisuales. Además, en los vídeos de científicos en acción, se muestran aplicaciones de estos conceptos mediante experimentos reales en laboratorios especializados.

new-jersey-student-learning-standards-for-science

New Jersey Student Learning Standards for Science

High School

Life Science

heredity-inheritance-and-variation-of-traits

Heredity: Inheritance and Variation of Traits

HS-LS3-1

Development of Antibiotic Resistance

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Understanding Species and Reproductive Barriers

A species is a group of organisms that interbreed and produce fertile offspring. Typically, individuals of the same species appear similar and share ...

Formation of Species

Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the ...

Speciation Rates

Speciation can proceed at markedly different rates, and evolutionary biologists commonly describe these differences through the models of gradualism and ...

Genetics of Speciation

Speciation is the evolutionary process resulting in the formation of new, distinct species&#x2014;groups of reproductively isolated populations.The ...

Hybrid Zones

Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may ...

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become ...

Types of Selection

Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural ...

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to ...

Limits to Natural Selection

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Natural Selection

Fitness
Widespread variation of phenotypes in natural populations provides the raw material for evolution, which is the change in the inherited traits of ...

Simulating Natural Selection
ExpandTo prepare for the lab, set out workstations for each student pair containing 6 white, 6 black, and 13 gray 12 inch ...

Simulating Natural Selection
ExpandTo begin, cut the white, black, and gray pipe cleaners into quarters, which should produce a total of 100 pieces that ...

Artificial Selection

Natural Selection and Adaptive Evolution
In natural settings, adaptive evolution takes place by natural selection, a process in which differences in ...

Observing Artificial Selection in Plants
ExpandTwo weeks before beginning the pollination experiments, collect a sufficient amount of small pots with a ...

Observing Artificial Selection in Plants 
ExpandTo begin the experiment, collect five two-week old grown plants from the generation one population that ...

Analyze and interpret data to summarize how various factors such as geographic isolation, pesticide resistance, antibiotic resistance can influence natural selection.

LS.Bio.9.1

Phylogenetic Trees

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Conditions on Early Earth

Around 4 billion years ago, oceans began to condense on earth while volcanic eruptions released nitrogen, carbon dioxide, methane, ammonia, and hydrogen ...

The Colonization of Land

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What is Evolutionary History?

Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and ...

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of ...

The Fossil Record

The fossil record documents only a small fraction of all organisms that have ever inhabited Earth. Fossilization is a rare process, and most organisms ...

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure ...

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain ...

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major ...

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes ...

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and ...

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower ...

Construct an explanation to illustrate how common ancestry and biological evolution are supported by multiple lines of empirical evidence.

Use models to illustrate the conditions required for natural selection, including the overproduction of offspring, inherited variation, and the struggle to survive.

LS.Bio.9.3

Construct an explanation to explain how natural selection leads to adaptations within populations.

LS.Bio.9.4

Extinction

The History of Life on Earth
Fossils of organisms that were different from anything alive today had been documented as early as the 17th century, but it ...

Diversity and Extinction during the Paleogene Epoch
ExpandFirst, familiarize yourself with the extinction reading supplement for the background on what ...

Diversity and Extinction during the Paleogene Epoch
ExpandBegin this procedure by reading the extinction reading supplement that has been printed out for ...

Construct explanations to illustrate how varying environmental conditions may result in: changes in the number of individuals of a species, the emergence of new species over time, or the extinction of other species.

LS.Bio.10.1

Synteny and Evolution

John H. Renwick first coined the term &#8220;synteny&#8221; in 1971, which refers to the genes present on the same chromosomes, even if they are not ...

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was ...

Taxonomy

Taxonomy is the science of defining and naming groups of biological organisms based on shared characteristics. It uses a hierarchy of increasingly ...

Phylogeny

Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon ...

Use models (including dichotomous keys, scientific nomenclature, cladograms, phylogenetic trees) to identify organisms and exemplify relationships.

LS.Bio.10.2

Understand natural selection as a mechanism for biological evolution.

How Gene Families Evolve and Diversify

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