Name: tracing traits with pedigree charts
Uploaded: 2021-04-07T12:11:58.000Z
Duration: 2 min 21 s
Channel: JoVE

K12 Standards

north-carolina-k-12-science-standard-course-of-study

North Carolina K-12 Science Standard Course of Study

9-12

Biology

heredity-inheritance-and-variation-of-traits

Heredity- Inheritance and Variation of Traits

LS.Bio.7.1

Pedigree Analysis

- [Narrador] Para entender c&#xF3;mo los rasgos

o des&#xF3;rdenes son heredados en los humanos,

los cient&#xED;ficos analizan el &#xE1;rbol familiar

tambi&#xE9;n conocido como pedigr&#xED;.

En un pedigr&#xED; t&#xED;pico,
lo cuadrados son machos,

los c&#xED;rculos indican hembras

y una l&#xED;nea horizontal entre estas figuras

representa el emparejamiento.

Si esta uni&#xF3;n produce ni&#xF1;os,

se dibuja una l&#xED;nea perpendicular
debajo de los padres

hacia los hijos e hijas.

Esto va haciendo filas
debajo progresivamente

en el pedigr&#xED;

representando a las generaciones
subsecuentes en la familia.

Para quienes demuestren
un fenotipo de enfermedad,

como erupciones en la piel asociadas con

el d&#xE9;ficit de biotinidasa

en el que una persona no
tiene la enzima necesaria

para obtener vitamina B7,

las formas asociadas en
la genealog&#xED;a se sombrean.

Al concluir qu&#xE9; miembros
de la familia han sido

diagnosticados con d&#xE9;ficit de biotinidasa,

los investigadores pueden determinar

si la enfermedad resulta

de una mutaci&#xF3;n recesiva o
dominante de un solo gen,

situados en un autosoma
o cromosoma sexual.

Aqu&#xED; las hembras y machos son
afectados de la misma forma.

Los padres no afectados
tienen hijos con ese desorden

y no cada generaci&#xF3;n tiene
a un miembro de la familia

con la enfermedad, un patr&#xF3;n que sugiere

que el d&#xE9;ficit de biotinidasa
es un autosoma recesivo.

De modo importante el an&#xE1;lisis
de pedigr&#xED; no s&#xF3;lo elucida

patrones heredados,

sino que tambi&#xE9;n ayudan
a las parejas a entender

su riesgo de tener un ni&#xF1;o con el desorden

dado en su historia familiar.

Chial, Heidi. 2008. "Genética mendeliana: patrones de herencia y trastornos de un solo gen". Educación de la Naturaleza 1 (1): 63. [<a href="https://www.nature.com/scitable/topicpage/mendelian-genetics-patterns-of-inheritance-and-single-966" target="__blank">Fuente</a>]

Germain, Dominique P. 2006. "Aspectos generales de las enfermedades ligadas al cromosoma X". En Fabry Disease: Perspectives from 5 Years of FOS, editado por Atul Mehta, Michael Beck y Gere Sunder-Plassmann. Oxford: Oxford PharmaGenesis. [<a href="https://www.ncbi.nlm.nih.gov/books/NBK11593/" target="__blank">Fuente</a>]

análisis de pedigree

<h4>Descripci&#xF3;n general</h4> Un pedigr&#xED; es un diagrama que muestra la historia de un rasgo en una familia. El an&#xE1;lisis de genealog&#xED;as puede revelar (1) si un rasgo es dominante o recesivo, (2) el tipo de cromosoma, autos&#xF3;mico o sexual, al que est&#xE1; vinculado un rasgo, (3) genotipos de miembros de la familia y (4) probabilidades de fenotipos en el futuro. generaciones. Para familias con antecedentes de enfermedades autos&#xF3;micas o ligadas al sexo, esta informaci&#xF3;n puede ser crucial para la planificaci&#xF3;n familiar. <h4>Los pedigr&#xED;es muestran historias familiares</h4> En diversas especies de plantas y animales, los cient&#xED;ficos estudian la herencia de fenotipos o rasgos mediante experimentos de apareamiento cuidadosamente controlados llamados cruces. Por ejemplo, los cruces monoh&#xED;bridos pueden establecer un rasgo de dominancia o recesividad, y los cruces de prueba pueden determinar el genotipo (homocigoto o heterocigoto) de un organismo que exhibe un fenotipo dominante conocido. Los seres humanos, sin embargo, no pueden ser contrariados ni desde el punto de vista &#xE9;tico ni factible. Por lo tanto, los investigadores analizan genealog&#xED;as o &#xE1;rboles geneal&#xF3;gicos para comprender c&#xF3;mo se heredan los rasgos y enfermedades humanos. Los pedigr&#xED;es muestran la historia familiar de un rasgo a trav&#xE9;s de generaciones y miembros de la familia. Utilizando los mismos principios que se aplican a los cruces para analizar eventos reproductivos que ya han ocurrido, se puede inferir informaci&#xF3;n sobre la heredabilidad de los rasgos. <h4>Las filas de un pedigr&#xED; representan generaciones de una familia</h4> En un pedigr&#xED; t&#xED;pico, los cuadrados representan machos y los c&#xED;rculos representan hembras. Los cuadrados o c&#xED;rculos sombreados indican la presencia de un rasgo de inter&#xE9;s. Las filas son generaciones, a veces etiquetadas con n&#xFA;meros romanos. La generaci&#xF3;n m&#xE1;s antigua comprende la fila superior, y cada generaci&#xF3;n posterior est&#xE1; en filas separadas. Dentro de cada generaci&#xF3;n, o fila, los miembros de la familia pueden etiquetarse num&#xE9;ricamente de izquierda a derecha y hacer referencia a ellos por su generaci&#xF3;n y posici&#xF3;n. Por ejemplo, el segundo individuo de la primera generaci&#xF3;n es I-2. Una l&#xED;nea horizontal que conecta a dos padres se llama l&#xED;nea matrimonial, aunque el matrimonio no necesariamente est&#xE1; involucrado. Una l&#xED;nea vertical de descendencia que se extiende hacia abajo desde una l&#xED;nea matrimonial se conecta a una l&#xED;nea horizontal de hermanos. Los individuos conectados a la l&#xED;nea de descendencia a trav&#xE9;s de la l&#xED;nea de hermanos son descendientes. Las personas que no est&#xE1;n directamente relacionadas con la l&#xED;nea de hermanos ingresaron a la familia a trav&#xE9;s de l&#xED;neas matrimoniales y no son descendientes biol&#xF3;gicos de la generaci&#xF3;n anterior. <h4>Los pedigr&#xED;es revelan informaci&#xF3;n sobre la herencia de rasgos y enfermedades</h4> Los rasgos dominantes se distribuyen de forma diferente a los recesivos. La herencia tambi&#xE9;n es distinta para los rasgos determinados por genes en los cromosomas sexuales en comparaci&#xF3;n con los rasgos vinculados a los autosomas (cromosomas no sexuales). Al examinar la presencia y ausencia de un rasgo a lo largo de la historia de una familia, el an&#xE1;lisis geneal&#xF3;gico puede proporcionar informaci&#xF3;n sobre la herencia del rasgo. Aunque muchas enfermedades est&#xE1;n influenciadas por m&#xFA;ltiples genes, varias muestran patrones de herencia mendeliana. Para estas condiciones, los pedigr&#xED;es pueden dar pistas importantes sobre el riesgo de herencia y propagaci&#xF3;n de enfermedades. Los rasgos causados por genes en los autosomas y que requieren dos copias de alelos para influir en un fenotipo son autos&#xF3;micos recesivos. Varios trastornos son autos&#xF3;micos recesivos, incluida la fibrosis qu&#xED;stica, la enfermedad de Tay-Sachs y la enfermedad de la orina con jarabe de arce. La mayor&#xED;a de las personas con estas enfermedades tienen padres heterocigotos que no padecen la afecci&#xF3;n pero que portan un alelo causal. Estos portadores pueden, sin saberlo, transmitir la enfermedad a sus hijos, lo que explica en parte por qu&#xE9; las enfermedades autos&#xF3;micas recesivas son m&#xE1;s comunes que sus contrapartes dominantes. La comparaci&#xF3;n de generaciones en un pedigr&#xED; puede revelar si un rasgo autos&#xF3;mico es dominante o recesivo. Ninguno de los padres tiene el rasgo, pero uno de los hijos lo hereda. Por tanto, debe ser recesivo. Las pecas y el polidactilismo (dedos adicionales en manos o pies) son rasgos autos&#xF3;micos dominantes en los humanos, que requieren solo una copia del alelo determinante para influir en el fenotipo. Las enfermedades autos&#xF3;micas dominantes, como la enfermedad de Huntington, afectan a aproximadamente el 50% de la descendencia con un progenitor afectado. Muchas de estas enfermedades no causan s&#xED;ntomas hasta una etapa m&#xE1;s avanzada de la vida, despu&#xE9;s de la edad reproductiva. Los ni&#xF1;os pueden heredar estas enfermedades de padres afectados sin saberlo, lo que destaca la importancia de analizar los antecedentes familiares. Aunque ambos padres exhiben el rasgo, uno de sus hijos no. Dado que un cruce entre dos padres recesivos produce consistentemente un fenotipo recesivo, este rasgo debe ser dominante. <h4>Los rasgos pueden ser autos&#xF3;micos o ligados al sexo</h4> Adem&#xE1;s de 44 autosomas, los humanos tenemos dos cromosomas sexuales, que son hom&#xF3;logos en las mujeres (XX), pero no hom&#xF3;logos en los hombres (XY). Los rasgos determinados por los cromosomas sexuales est&#xE1;n ligados al sexo. La mayor&#xED;a de los rasgos ligados al sexo en los seres humanos son recesivos ligados al cromosoma X. S&#xF3;lo los hombres pueden heredar rasgos ligados al Y porque las mujeres carecen de un cromosoma Y. Adem&#xE1;s, el cromosoma X contiene entre 800 y 900 genes codificadores de prote&#xED;nas, en comparaci&#xF3;n con los 70 a 80 del cromosoma Y. Los rasgos ligados al cromosoma X incluyen hemofilia, distrofia muscular y daltonismo rojo-verde. Dado que los hombres tienen s&#xF3;lo un cromosoma X, son hemicigotos (en lugar de homocigotos o heterocigotos) para un rasgo ligado al cromosoma X. Los hombres son m&#xE1;s susceptibles a los rasgos recesivos ligados al cromosoma X que las mujeres porque no tienen un segundo alelo que pueda enmascarar potencialmente un alelo recesivo causal.

Análisis de Pedigree

Overview

A pedigree is a diagram displaying a family&#x2019;s history of a trait. Analyzing pedigrees can reveal (1) whether a trait is dominant or ...

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Education

Educación

JoVE Core

Molecular Biology

Biología Molecular

Unit 2

Unidad 2

Mendelian Genetics

Genética mendeliana

KEY TERMS AND CONCEPTS

TÉRMINOS Y CONCEPTOS CLAVE

tracing traits with pedigree charts

Pedigree analysis uses family trees, called pedigrees, to trace how traits and diseases pass from one generation to the next. A pedigree chart helps scientists and students see inheritance patterns clearly across relatives.

The chart uses standard symbols to show family members and their relationships. It can reveal whether a trait is likely passed through dominant or recessive inheritance, and it can also help identify patterns linked to sex chromosomes.

By studying a pedigree, it is possible to follow a trait through multiple generations and compare affected and unaffected individuals. This makes pedigree analysis a useful tool for understanding genetic inheritance and for predicting how a trait may appear in future family members.

Tracing Traits with Pedigree Charts

punnett squares

Predicting Traits with Punnett Squares

Punnett squares help students predict how traits may be passed from parents to offspring. They are a simple grid used in genetics to organize possible allele combinations. An allele is a version of a gene. The square compares the alleles each parent can give. By filling in the boxes, students can see possible genotypes, which are the genetic makeup of offspring. The results can also help connect those genotypes to traits that may appear in the next generation.

monohybrid crosses

Tracking One Trait in Monohybrid Crosses

Monohybrid crosses track how one trait is passed from parents to offspring. They are used to study inheritance when only a single characteristic is followed at a time. A monohybrid cross can compare the possible outcomes for a monogenic trait, which is a trait controlled by one gene. This approach helps show how one gene can shape different inherited forms of the same characteristic. The method also connects with Mendel's work on genetics. It is a useful way to predict patterns of inheritance...

dihybrid crosses

Predicting Two-Trait Genetic Crosses

Dihybrid crosses are used to predict how two traits can be passed from parents to offspring. A dihybrid cross tracks two genes at the same time, so it helps students see how different alleles can combine in a genetic pattern. This topic is closely tied to Mendelian genetics and independent assortment. Independent assortment means that allele pairs for different traits can separate into gametes independently of one another. When students work through a dihybrid cross, they can compare the...

trihybrid crosses

Forked Line Method for Trihybrid Crosses

Forked line method for trihybrid crosses helps predict the outcome of three-trait Mendelian crosses. A trihybrid cross studies three pairs of contrasting characteristics. It combines three separate monohybrid crosses. Common examples include plant height, seed shape, and seed color. In a typical trihybrid cross, the F1 plants are heterozygous for all three traits. They can produce eight different gametes. After self-fertilization, these gametes can lead to 64 genotype combinations in the F2...

law of independent assortment

Independent Chromosome Assortment in Meiosis

Independent chromosome assortment in meiosis explains how different gene pairs can be inherited independently. This idea is one of Mendel’s laws of inheritance and is often called the law of independent assortment. The pattern depends on how homologous chromosomes line up during meiosis I. Each chromosome pair orients independently of the others, so the maternal and paternal chromosomes can separate into different gametes in many combinations. This random separation helps create genetic...

chi-square analysis

Chi-Square Test in Genetics

The chi-square test in genetics helps compare expected and observed results. It is a statistical hypothesis test used to see whether a difference between an expected value and an observed value is significant. In genetics, it helps decide whether to accept or reject a hypothesis based on how far the observed data moves from the expected data. The test was developed by Pearson in 1990. The first step is to set up a null hypothesis. This hypothesis says there is no real difference between the...

pedigree analysis

Pedigree analysis uses family trees, called pedigrees, to trace how traits and diseases pass from one generation to the next. A pedigree chart helps scientists and students see inheritance patterns clearly across relatives. The chart uses standard symbols to show family members and their relationships. It can reveal whether a trait is likely passed through dominant or recessive inheritance, and it can also help identify patterns linked to sex chromosomes. By studying a pedigree, it is...

multiple allele traits

Multiple Alleles in Trait Inheritance

Multiple alleles can shape how a trait is inherited in a population. A gene may have more than two allele forms, even though each person still carries only two alleles for that gene. These allele combinations can produce traits with more than two possible outcomes. The ABO blood group system is a common example of a multiple allele trait. It shows how different alleles can interact to determine an organism’s phenotype, or observable trait. Multiple allele traits help explain why inheritance...

incomplete dominance

Incomplete Dominance in Traits and Disease

Incomplete dominance is a pattern of inheritance where two alleles both affect a trait in a heterozygous organism. In this case, one allele is not fully dominant over the other. The result is a phenotype that looks like a blend or intermediate form. Gregor Mendel’s pea plant experiments helped explain the usual dominant and recessive pattern. He showed that each gene in a diploid cell has two alleles, one inherited from each parent. In his model, a dominant allele shows its effect with one or...

lethal alleles

When Genes Cause Embryonic Death

Lethal alleles can change inheritance patterns by causing death before birth. In mice, Lucien Cuénot studied the agouti gene, which helps control coat color through an agouti-signaling protein that affects melanin distribution in mammals. The wild-type allele produces a gray-brown coat, while the mutant allele produces a yellow coat. Cuénot also found that the yellow allele was linked to yellow mouse obesity syndrome. This syndrome is associated with early-onset obesity and tumors. When he...

polygenic traits

Traits Shaped by Many Genes

Polygenic traits are characteristics shaped by many genes acting together. This pattern is different from a single-gene trait, where one gene has a larger effect on the outcome. In polygenic inheritance, each gene adds a small contribution to the final trait. Height is a common example of a polygenic trait. Many genes influence human height, so the result can vary across a wide range. These small genetic effects combine to produce differences that are easy to see in a population. Polygenic...

background and environment affect phenotype

background-and-environment-affect-phenotype

How Genes and Environment Shape Traits

Genes and the environment work together to shape phenotype, or the visible traits of an organism. A phenotype can change because of genetic background, environmental conditions, or both. Factors such as temperature, oxygen availability, and mutagens can all influence how a trait appears. Horses show how one gene can affect coat color and how a modifier gene can change that result. The Extension gene controls pigment production in the coat. The wild-type genotype EE produces black pigment,...

x and y chromosomes

Sex Chromosomes in Human Inheritance

Sex chromosomes help determine biological sex in mammals, including humans. Humans have two sex chromosomes, X and Y. Each diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A female usually has two X chromosomes, while a male usually has one X chromosome and one Y chromosome. Egg and sperm cells carry only half the usual number of chromosomes. They contain 22 autosomes and one sex chromosome. Every egg has an X chromosome. Sperm cells can carry either an X or a Y...

the y chromosome determines maleness

Y Chromosome Structure and Male Traits

The Y chromosome is a sex chromosome that helps guide male development in humans and other vertebrates and mammals. Human males usually have one X chromosome and one Y chromosome, along with 22 pairs of autosomes. In these organisms, the presence or absence of the Y chromosome influences whether male traits develop. The Y chromosome evolved from an autosome about 300 million years ago, when two sex chromosomes began to diverge. Since then, it has lost most of its genes and become much smaller.

the ratio of x chromosome to autosomes

Drosophila Sex Determination by X:A Balance

In Drosophila, sex is determined by the balance between X chromosomes and autosomes, not by the X and Y chromosomes alone. The Y chromosome is active in these flies, but it does not set sex. Instead, it carries genes needed for sperm production in adult males. A normal male Drosophila has one X chromosome and two sets of autosomes. A normal female has two X chromosomes and two sets of autosomes. When this X:A ratio changes, flies can develop different sexual phenotypes, including metamales,...

x-linked traits

X-Linked Inheritance in Families

X-linked inheritance in families explains how traits linked to the X chromosome pass from parents to children. These traits are often tracked through family trees because the pattern can differ between males and females. A male has one X chromosome and one Y chromosome. A female has two X chromosomes. Because of this difference, a trait on the X chromosome can show up in a different way depending on the sex of the child. Family examples often include traits such as color blindness. Studying...

sex linked disorders

Sex-Linked Disorders and Inheritance Patterns

Sex-linked disorders are genetic conditions that follow inheritance patterns tied to the sex chromosomes. These disorders help explain how certain traits can appear more often in one sex than the other. The transcript focuses on examples of sex-linked disorders, including Y-linked infertility, Fragile X syndrome, and Duchenne muscular dystrophy. Y-linked infertility is passed through the Y chromosome, while Fragile X syndrome and Duchenne muscular dystrophy are associated with sex-linked...

dosage compensation

X-Chromosome Balance in Animals

X-chromosome balance in animals helps equalize gene expression between males and females. Sex can be determined by the number and type of sex chromosomes. In humans, females have two X chromosomes and males have one X and one Y chromosome. In C. elegans, one X chromosome is male, while two X chromosomes make a hermaphrodite. The X chromosome carries more than sex-related genes. It also includes genes involved in body functions such as brain development and the immune system. Because males and...

x-inactivation

X-Inactivation and Barr Bodies

X-inactivation is a process that reduces gene activity on one X chromosome. It helps balance gene expression in cells that have more than one X chromosome. A key result of this process is the formation of a Barr body, which is the inactive X chromosome seen in the nucleus. This topic also includes Xist, a gene linked to X-inactivation. Xist produces RNA that coats the X chromosome and helps turn it off. Together, Xist and the Barr body show how cells control X-linked genes during development...

blood types

Blood Types and Transfusion Matching

Human blood types help determine safe blood transfusion matching. Blood is classified by antigens on the surface of red blood cells and antibodies in the plasma. Correct blood typing matters because an unsafe match can affect transfusion success. The International Society of Blood Transfusion has identified 38 human blood types, and ABO, Rh, and MNS are among the most common. The ABO blood group depends on antigens made by genes on chromosome 9. Red blood cells carry a base glycoprotein called...

blood transfusion and agglutination

Matching Blood Types for Safe Transfusion

Blood transfusion is a medical treatment used to restore blood volume after major blood loss from an accident or a medical procedure. It works by taking blood from a suitable donor and giving it to a recipient. Safe transfusion depends on matching blood types and checking for immune compatibility. The history of blood transfusion began in the 17th century, when early experiments were done in animals. In 1818, James Blundell, a British doctor, performed the first successful human blood...

key terms and concepts

Learn how pedigree charts track traits and diseases across generations, showing inheritance patterns such as dominant, recessive, and sex-linked traits.

Tracing Traits with Pedigree Charts | JoVE K12

molecular biology

JoVE Core Biología Molecular presenta los procesos moleculares de la célula a través de lecciones claras y concisas de animaciones audiovisuales. Además, en los vídeos de científicos en acción, se muestran aplicaciones de estos conceptos mediante experimentos reales en laboratorios especializados.

Louisiana Student Standards for Science

High School

Life Sciences

Heredity: Inheritance And Variation Of Traits

HS-LS3-1

ohios-learning-standards-and-model-curriculum

Ohio’s Learning Standards and Model Curriculum

Heredity

Genetic mechanisms and inheritance

Alabama Course of Study Science

Heredity: Inheritance and Variation of Traits

9-12.B.3.11

Florida Department of Education

Life Science

SC.912.L.16

SC.912.L.16.2

Texas Essential Knowledge and Skills

BIO.8

BIO.8.B

What is Meiosis?

Meiosis is the process by which diploid cells divide to produce haploid daughter cells. In humans, each diploid cell contains 46 chromosomes, half from ...

Meiosis I

Meiosis II

Meiosis vs. Mitosis

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to ...

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This ...

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of ...

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from ...

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ...

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage ...

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of ...

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three ...

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms ...

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. ...

Use models to explain how DNA is passed from parents to offspring through the processes of meiosis and fertilization in sexual reproduction.

LS.Bio.6.1

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations ...

genome-size-and-the-evolution-of-new-genes

Genome Size and the Evolution of New Genes

types-of-genetic-transfer-between-organisms

Types of Genetic Transfer Between Organisms

Base-pairing and DNA Repair

The DNA Replication Fork

Lagging Strand Synthesis

The Replisome

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template ...

Replication in Prokaryotes

DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the ...

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before ...

Overview of DNA Repair

Base Excision Repair

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens&#8212;factors in the environment that can damage DNA and generate mutations. UV ...

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the ...

Fixing Double-strand Breaks

Homologous Recombination

Gene Conversion

Restarting Stalled Replication Forks

Construct an explanation to summarize how inheritable genetic variations may result from: new genetic combinations in meiosis, mutations during replication, or mutations caused by environmental factors.

LS.Bio.6.2

An Overview of Genetic Analysis

An organism&#8217;s physical traits, or phenotype, are a product of its genotype, which is the combination of alleles (gene variants) inherited from its ...

Genetic Crosses

To dissect genetic processes or create organisms with novel suites of traits, scientists can perform genetic crosses, or the purposeful mating of two ...

Punnett Squares

Monohybrid Crosses

Dihybrid Crosses

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel&#8217;s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A ...

Law of Independent Assortment

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an ...

Multiple Allele Traits

Incomplete Dominance

Gregor Mendel&#39;s work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid ...

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cu&#233;not discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is ...

Polygenic Traits

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as ...

Use mathematics and computational thinking to predict the variation and distribution of expressed traits based on: Mendelian inheritance, co-dominance, incomplete dominance, multiple alleles, and sex-linked inheritance.

Probability Laws

Overview

The probability of inheriting a trait can be calculated using the sum and product rules. The sum rule is used to calculate the probability of ...

The Concept of Multiple Allelism

Multiple allelism describes genes that exist in three or more allelic forms. Although diploid organisms, like humans, ...

Analyze and interpret data to explain how polygenic traits result in a wide range of phenotypes.

LS.Bio.7.2

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause ...

Nature and Nurture

Many human characteristics, like height, are shaped by both nature&mdash;in other words, by our genes&mdash;and by nurture, or our environment. For ...

Construct an explanation to summarize how traits result from interactions of genetic factors (multiple genes and/or alleles) and environmental factors.

LS.Bio.7.3

Understand genetic mechanisms for variation.

Tracing Traits with Pedigree Charts

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