Pi(4

PI(4)P, also called phosphatidylinositol 4-phosphate, is a signaling phospholipid that helps organize cellular membranes and regulate biochemical communication. Cells produce it by phosphorylating phosphatidylinositol at the 4-position through phosphatidylinositol 4-kinases, while phosphatases remove the phosphate to control its abundance and distribution. PI(4)P contributes to membrane identity, recruits proteins with lipid-binding domains, and supports vesicle trafficking and phosphoinositide metabolism. Studying its synthesis, turnover, and interactions helps clarify how cells coordinate intracellular transport and signaling, with relevance to membrane biology, metabolic regulation, and diseases linked to disrupted phosphoinositide homeostasis.

Pi(4 - Related Videos

Education

JoVE Core - Civil Engineering

The Buckingham Pi Theorem

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2025

The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms. In analyzing flow through a pipe, variables that define the system include the pipe's diameter, the fluid's velocity, its density, and viscosity. These can be combined into a single dimensionless term, the Reynolds number (Re), which captures their essential relationship. The first step in applying the Buckingham Pi theorem is identifying...

Determination of Pi Terms

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2025

The Buckingham Pi theorem is a valuable method in dimensional analysis, reducing complex relationships between variables into dimensionless terms. Relevant variables in analyzing the lift force on an airplane wing include lift force, air density, wing area, aircraft velocity, and air viscosity. Expressing each variable in terms of fundamental dimensions — mass, length, and time — provides a consistent foundation for constructing these dimensionless terms. The theorem indicates that the number...

PI Controller: Design

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2024

Proportional Integral (PI) controllers are a fundamental component in modern control systems, widely used to enhance performance and mitigate steady-state errors. They are particularly effective in applications such as automatic brightness adjustment on smartphones, where they excel at mitigating steady-state errors for step-function inputs. Unlike PD controllers, which require time-varying errors to function optimally, PI controllers leverage their integral component to address residual...

Time and frequency -Domain Interpretation of PI Control

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2024

Proportional-Integral (PI) controllers are essential in many control systems to improve stability and performance. They are commonly used in everyday devices like thermostats to enhance system damping and reduce steady-state error. When the zero in the controller's transfer function is optimally placed, the system benefits significantly in terms of stability and accuracy. Acting as a low-pass filter, the PI controller slows the system's response and extends settling times. This requires careful...

Research

JoVE Journal - Immunology and Infection

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 4. Medical Imaging Procedures

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Cited by 8 •

2016

Here, we present an overview of the preparation and animal handling procedures required to safely perform medical imaging in an animal biosafety level 4 laboratory. Computed tomography of a mock-infected guinea pig illustrates these procedures that may be used to evaluate the disease caused by a high consequence pathogen.

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