Surgical Mi Model
Surgical Mi Model - Related Videos
05:19
Surgical Models of Gastroesophageal Reflux with Mice
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Cited by 8 •
2015
This article demonstrates surgical procedures of gastroesophageal reflux with mice. These models are useful tools for research on mechanisms and treatment of gastroesophageal reflux disease and potentially Barrett’s esophagus and esophageal adenocarcinoma.
10:10
A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail
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Cited by 24 •
2016
Here we present a murine model of arteriovenous fistula (AVF) failure in which a clinically relevant anastomotic configuration is incorporated. This model can be used to study the pathophysiology and to test possible therapeutic interventions.
04:58
Mouse Ileal Loop Model: A Surgical Model to Study Intestinal Permeability in the Mouse
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2025
This video demonstrates the generation of an ileal loop model to study intestinal permeability in a mouse model. This method provides a live model to understand the epithelial barrier function and consequent immune response.
04:36
Surgical Induction of Lumbar Spine Instability in Mouse Model: A Surgical Procedure for the Resection of the Lumbar Spinous Processes and Connected Ligaments in Murine Model
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2025
In this video, we describe the surgical procedure to induce lumbar spine instability in a mouse model by resecting the Lumbar L3 to L5 spinous process along with supraspinous and interspinous ligaments.
08:02
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
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Cited by 62 •
2012
A description of the surgical induction of endometriosis in mice and rats by auto-transplantation of uterine tissue to the arterial cascade of the intestinal mesentery.
FAQs
The extent and timing of coronary restriction determine the injury pattern in a Surgical MI Model. A permanent ligation interrupts flow, whereas temporary occlusion creates a defined ischemic interval. Varying these conditions allows investigators to compare infarct severity, ventricular remodeling, and recovery across experimental groups.
The left anterior descending coronary artery is commonly selected because the protocol can target it consistently after the heart is exposed through a thoracotomy. Ligating or temporarily occluding this vessel creates a reproducible reduction or interruption of coronary blood flow, helping investigators relate a defined surgical event to subsequent cardiac injury and repair.
Following the induced injury, investigators can examine ventricular remodeling, inflammation, scar formation, and functional decline as separate but related outcomes. Together, these measures show how the heart changes during injury and repair rather than limiting assessment to the initial loss of blood flow. This multidimensional view helps compare disease progression and treatment effects.
An experimental workflow begins with thoracotomy to access the heart, followed by ligation or temporary occlusion of the left anterior descending coronary artery. The chosen approach establishes the intended reduction or interruption in blood supply, after which researchers assess injury, repair, remodeling, or function. Controlled timing and severity make comparisons among experimental groups possible.
Researchers apply the model to test cardioprotective drugs, cell-based therapies, biomaterials, and regenerative strategies. Its value lies in placing these interventions within a controlled setting where investigators can compare how treatments influence cardiac injury, scar formation, ventricular remodeling, inflammation, or functional decline. The same framework supports therapeutic screening and studies of post-MI healing.
In medicine, the Surgical MI Model connects a controlled coronary-flow injury with clinically relevant consequences in the heart, including scarring, remodeling, inflammation, and declining function. Researchers can use this connection to investigate post-MI healing and determine whether a drug, cell product, biomaterial, or regenerative strategy changes the course of cardiac recovery.