Rare Fossil Studies

Rare fossil studies investigate exceptionally scarce fossil specimens to reconstruct ancient organisms, environments, and evolutionary history from limited evidence. In statistics, researchers quantify uncertainty by describing small samples, comparing observed traits or occurrences with expected patterns, and accounting for sampling bias, preservation, and incomplete discovery. These methods help distinguish genuine biological signals from patterns created by uneven fossil records, such as apparent changes in diversity or geographic range. Statistical analysis therefore strengthens interpretations of rare fossils, supports more transparent comparisons across geological deposits, and guides decisions about which discoveries or additional sampling could most improve scientific understanding.

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Education

JoVE Core - Biology

The Fossil Record

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2026

The fossil record documents only a small fraction of all organisms that have ever inhabited Earth. Fossilization is a rare process, and most organisms never become fossils. The fossil record includes only fossils that have been discovered. As a result, it is biased toward long-lived, abundant, hard-bodied organisms preserved in sedimentary rock. Nevertheless, these fossils provide valuable information about an organism’s physical form, behavior, and age. Along with body fossils, trace...

Research

JoVE Journal - Biology
Free Sample

Using Archival Japanese Paper and Thermoplastic Resins to Prepare Fossils for Storage, Display, Transport, and Radiography

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2025

This article presents a suite of techniques for reconstructing fossil specimens using paper-resin composites. These composites are made by combining archival-grade paper with thermoplastic resins commonly used in fossil preparation laboratories. The resulting lightweight composites add long-term stability to specimens while retaining suitability for radiological analyses.

Research

JoVE Journal - Biology
Free Sample

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

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Cited by 10 •

2012

Pooled DNA sequencing is a fast and cost-effective strategy to detect rare variants associated with complex phenotypes in large cohorts. Here we describe the computational analysis of pooled, next-generation sequencing of 32 cancer-related genes using the SPLINTER software package. This method is scalable, and applicable to any phenotype of interest.

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

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Cited by 43 •

2019

The goal of this protocol is to outline the design and performance of in vivo experiments in Drosophila melanogaster to assess the functional consequences of rare gene variants associated with human diseases.

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

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Cited by 36 •

2017

A simple yet effective method that employs magnetic nanoparticles to detect and enrich antigen-reactive B cells for functional and phenotypic analysis is described.

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