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Legatura parziale del nervo sciatico
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Legatura parziale del nervo sciatico: un modello murino di dolore neuropatico cronico per studiare l'effetto antinocicettivo di nuove terapie

Article DOI: 10.3791/64555-v • 08:16 min • October 6th, 2022
October 6th, 2022 •
1, 1, 2, 1, 1, 5, *1,2,3,4, *1,2
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, 2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, 3Neuroscience Graduate Interdisciplinary Program, College of Medicine, The University of Arizona, Tucson, 4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, 5Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center
* These authors contributed equally

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La legatura parziale del nervo sciatico induce dolore neuropatico cronico di lunga durata, caratterizzato da risposte esagerate agli stimoli termici e meccanici. Questo modello murino di dolore neuropatico è comunemente usato per studiare terapie innovative per la gestione del dolore. Questo articolo descrive in dettaglio la procedura chirurgica per migliorare la standardizzazione e la riproducibilità.

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Medicina Numero 188
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