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JoVE Core

Molecular Biology

Video textbook for undergraduate courses: Visualized concepts and experiments

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20 Chapters

250+ Videos

2,100+ Multiple Choice Questions

Table of Contents

Chapter 1

DNA, Cells, and Evolution

10 Videos

20 Minutes

The DNA Helix

The DNA Helix

56K views

The Central Dogma

The Central Dogma

37.4K views

Prokaryotic cells

Prokaryotic cells

17.1K views

Eukaryotic Compartmentalization

Eukaryotic Compartmentalization

9.7K views

The Tree of Life – Bacteria, Archaea, Eukaryotes

The Tree of Life – Bacteria, Archaea, Eukaryotes

33K views

Mutations

Mutations

9K views

Gene Evolution – Fast or Slow?

Gene Evolution – Fast or Slow?

7.3K views

Genome Size and the Evolution of New Genes

Genome Size and the Evolution of New Genes

8.1K views

Gene Families

Gene Families

8.9K views

Types of Genetic Transfer Between Organisms

Types of Genetic Transfer Between Organisms

29.1K views

Chapter 2

Biochemistry of the Cell

11 Videos

26 Minutes

The Periodic Table and Organismal Elements

The Periodic Table and Organismal Elements

18.8K views

Functional Groups

Functional Groups

40K views

Polymers

Polymers

27.4K views

What are Lipids?

What are Lipids?

28.3K views

Structure of Lipids

Structure of Lipids

18.5K views

Chemistry of Carbohydrates

Chemistry of Carbohydrates

29.7K views

Nucleic Acids

Nucleic Acids

23.3K views

Intermolecular Forces

Intermolecular Forces

17K views

Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

52.4K views

pH

22K views

Hydrolysis of ATP

Hydrolysis of ATP

6.2K views

Chapter 3

Protein Structure

11 Videos

24 Minutes

What are Proteins?

What are Proteins?

20.3K views

Protein Organization

Protein Organization

20.6K views

Protein Folding

Protein Folding

32K views

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

11.1K views

Globular and Fibrous Proteins

Globular and Fibrous Proteins

44K views

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins

18K views

Protein Complex Assembly

Protein Complex Assembly

10.7K views

Conjugated Proteins

Conjugated Proteins

18.4K views

Amyloid Fibrils

Amyloid Fibrils

9.7K views

Antibody Structure

Antibody Structure

13.7K views

Protein Families

Protein Families

15.6K views

Chapter 4

Protein Function

17 Videos

32 Minutes

Ligand Binding Sites

Ligand Binding Sites

13K views

Protein-protein Interfaces

Protein-protein Interfaces

12.6K views

Conserved Binding Sites

Conserved Binding Sites

4.3K views

The Equilibrium Binding Constant and Binding Strength

The Equilibrium Binding Constant and Binding Strength

14.4K views

Cofactors and Coenzymes

Cofactors and Coenzymes

7.5K views

Allosteric Regulation

Allosteric Regulation

14.1K views

Ligand Binding and Linkage

Ligand Binding and Linkage

4.9K views

Cooperative Allosteric Transitions

Cooperative Allosteric Transitions

8K views

Phosphorylation

Phosphorylation

6.2K views

Protein Kinases and Phosphatases

Protein Kinases and Phosphatases

13.3K views

GTPases and their Regulation

GTPases and their Regulation

8.5K views

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

6.9K views

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

2.6K views

Mechanical Protein Functions

Mechanical Protein Functions

5K views

Structural Protein Function

Structural Protein Function

28.1K views

Protein Networks

Protein Networks

4.1K views

Allosteric Proteins-ATCase

Allosteric Proteins-ATCase

5.8K views

Chapter 5

DNA and Chromosome Structure

20 Videos

45 Minutes

DNA Packaging

DNA Packaging

31.5K views

DNA as a Genetic Template

DNA as a Genetic Template

22.5K views

Organization of Genes

Organization of Genes

12.6K views

Chromosome Structure

Chromosome Structure

23.2K views

Chromosome Replication

Chromosome Replication

8.9K views

The Nucleosome

The Nucleosome

16.5K views

The Nucleosome Core Particle

The Nucleosome Core Particle

12.3K views

Nucleosome Remodeling

Nucleosome Remodeling

9.4K views

Chromatin Packaging

Chromatin Packaging

15.7K views

Karyotyping

Karyotyping

10.4K views

Position-effect Variegation

Position-effect Variegation

6.4K views

Histone Modification

Histone Modification

13.6K views

Spreading of Chromatin Modifications

Spreading of Chromatin Modifications

8.4K views

Lampbrush Chromosomes

Lampbrush Chromosomes

8K views

Polytene Chromosomes

Polytene Chromosomes

10.2K views

Histone Variants at the Centromere

Histone Variants at the Centromere

4.4K views

Inheritance of Chromatin Structures

Inheritance of Chromatin Structures

6.4K views

Euchromatin

Euchromatin

7.1K views

Chromatin Position Affects Gene Expression

Chromatin Position Affects Gene Expression

23.6K views

Heterochromatin

Heterochromatin

14.2K views

Chapter 6

DNA Replication

16 Videos

32 Minutes

Replication in Prokaryotes

Replication in Prokaryotes

52.6K views

Replication in Eukaryotes

Replication in Eukaryotes

44.5K views

DNA Base Pairing

DNA Base Pairing

28.1K views

The DNA Replication Fork

The DNA Replication Fork

36.5K views

Proofreading

Proofreading

14.9K views

Lagging Strand Synthesis

Lagging Strand Synthesis

53.9K views

DNA Helicases

DNA Helicases

22K views

The Replisome

The Replisome

34.5K views

Mismatch Repair

Mismatch Repair

9.6K views

DNA Topoisomerases

DNA Topoisomerases

31.6K views

Telomeres and Telomerase

Telomeres and Telomerase

23.8K views

Non-nuclear Inheritance

Non-nuclear Inheritance

4.4K views

Animal Mitochondrial Genetics

Animal Mitochondrial Genetics

7.9K views

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

12.7K views

Export of Mitochondrial and Chloroplast Genes

Export of Mitochondrial and Chloroplast Genes

3.7K views

Single-Strand DNA Binding Proteins

Single-Strand DNA Binding Proteins

14.8K views

Chapter 7

DNA Repair and Recombination

16 Videos

37 Minutes

Overview of DNA Repair

Overview of DNA Repair

31.4K views

Base Excision Repair

Base Excision Repair

22.8K views

Long-patch Base Excision Repair

Long-patch Base Excision Repair

7.1K views

Nucleotide Excision Repair

Nucleotide Excision Repair

11.6K views

Translesion DNA Polymerases

Translesion DNA Polymerases

10.1K views

Fixing Double-strand Breaks

Fixing Double-strand Breaks

12.8K views

DNA Damage can Stall the Cell Cycle

DNA Damage can Stall the Cell Cycle

9.3K views

Homologous Recombination

Homologous Recombination

50.9K views

Restarting Stalled Replication Forks

Restarting Stalled Replication Forks

5.9K views

Gene Conversion

Gene Conversion

9.9K views

Overview of Transposition and Recombination

Overview of Transposition and Recombination

16K views

DNA-only Transposons

DNA-only Transposons

14.7K views

Retroviruses

Retroviruses

12.6K views

LTR Retrotransposons

LTR Retrotransposons

17.8K views

Non-LTR Retrotransposons

Non-LTR Retrotransposons

11.7K views

Conservative Site-specific Recombination and Phase Variation

Conservative Site-specific Recombination and Phase Variation

6.1K views

Chapter 8

Transcription: DNA to RNA

21 Videos

41 Minutes

What is Gene Expression?

What is Gene Expression?

30.8K views

RNA Structure

RNA Structure

27.1K views

RNA Stability

RNA Stability

10.7K views

Bacterial RNA Polymerase

Bacterial RNA Polymerase

30.2K views

Types of RNA

Types of RNA

26.7K views

Transcription

Transcription

39K views

Transcription Factors

Transcription Factors

21.3K views

RNA Polymerase II Accessory Proteins

RNA Polymerase II Accessory Proteins

9.3K views

Transcription Elongation Factors

Transcription Elongation Factors

11.1K views

Eukaryotic RNA Polymerases

Eukaryotic RNA Polymerases

24.5K views

Pre-mRNA Processing

Pre-mRNA Processing

27.2K views

RNA Splicing

RNA Splicing

17.5K views

Chromatin Structure Regulates pre-mRNA Processing

Chromatin Structure Regulates pre-mRNA Processing

7.1K views

Nuclear Export of mRNA

Nuclear Export of mRNA

7.8K views

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

13.4K views

Transfer RNA Synthesis

Transfer RNA Synthesis

12.2K views

The Nucleolus

The Nucleolus

9K views

Additional Subnuclear Structures

Additional Subnuclear Structures

4.7K views

Alternative RNA Splicing

Alternative RNA Splicing

21.6K views

Bacterial Transcription

Bacterial Transcription

29.2K views

Transcription Initiation

Transcription Initiation

16.6K views

Chapter 9

Translation: RNA to Protein

11 Videos

24 Minutes

Translation

Translation

51.7K views

tRNA Activation

tRNA Activation

19.8K views

Ribosomes

Ribosomes

25.2K views

Improving Translational Accuracy

Improving Translational Accuracy

11.8K views

Initiation of Translation

Initiation of Translation

34.4K views

Termination of Translation

Termination of Translation

25.6K views

Nonsense-mediated mRNA Decay

Nonsense-mediated mRNA Decay

10.7K views

Molecular Chaperones and Protein Folding

Molecular Chaperones and Protein Folding

18.2K views

The Proteasome

The Proteasome

8.9K views

Regulated Protein Degradation

Regulated Protein Degradation

7.5K views

Proteins: From Genes to Degradation

Proteins: From Genes to Degradation

12.5K views

Chapter 10

Gene Expression

15 Videos

32 Minutes

Cell Specific Gene Expression

Cell Specific Gene Expression

13.7K views

Regulation of Expression Occurs at Multiple Steps

Regulation of Expression Occurs at Multiple Steps

23K views

Cis-regulatory Sequences

Cis-regulatory Sequences

10K views

Cooperative Binding of Transcription Regulators

Cooperative Binding of Transcription Regulators

6.5K views

Prokaryotic Transcriptional Activators and Repressors

Prokaryotic Transcriptional Activators and Repressors

21.7K views

Operons

Operons

16.5K views

The Eukaryotic Promoter Region

The Eukaryotic Promoter Region

16.6K views

Co-activators and Co-repressors

Co-activators and Co-repressors

7.4K views

Eukaryotic Transcription Activators

Eukaryotic Transcription Activators

11.2K views

Eukaryotic Transcription Inhibitors

Eukaryotic Transcription Inhibitors

10K views

Combinatorial Gene Control

Combinatorial Gene Control

8.4K views

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

3.5K views

Master Transcription Regulators

Master Transcription Regulators

7K views

Epigenetic Regulation

Epigenetic Regulation

24.6K views

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

35K views

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