Chapter 17
Pharmacotherapy of the Epilepsies
Chapter 17
Pharmacotherapy of the Epilepsies
Epilepsy is a chronic neurological disorder characterized by recurrent, unpredictable seizures.
Seizures result from abnormal electrical discharges in the …
Epilepsy is a chronic neurological disorder characterized by unpredictable seizures.
Seizures can be provoked by identifiable factors or occur …
Antiepileptic drugs, essential in managing epilepsy, effectively prevent seizures by blocking the movement of sodium ions through channels in the …
γ-aminobutyric acid or GABA pathway potentiators are drugs used to manage epilepsy by enhancing GABA neurotransmission, a critical inhibitory pathway …
Calcium channel blockers, primarily known for cardiovascular use, have also shown potential as antiepileptic drugs. They exert their effects by modulating …
Glutamate is the primary excitatory neurotransmitter in the brain, essential for neuronal communication.
It plays a crucial role in synaptic transmission, …
Antiepileptic drugs, like levetiracetam and brivaracetam, leverage the synaptic vesicle protein SV2A to mitigate seizures.
SV2A is a transmembrane …
The Antiepileptic drug ezogabine functions as a potassium channel activator by enhancing transmembrane potassium currents mediated by the KCNQ subtype of …
Approximately 30% of epilepsy patients are refractory to antiepileptic drugs. In these cases, surgery is the only alternative to eliminate/control …
Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe seizure at a high …
Epilepsy is a group of neurological disorders which affects millions of people worldwide. Although treatment with medication is helpful in 70% of the …