Core Sheath Scaffold
Core Sheath Scaffold - Related Videos
09:17
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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Cited by 2 •
2025
This study presents a protocol for fabricating core-sheath 3D-bio-printed scaffolds for chronic wound healing. Extracellular vesicles are isolated from mesenchymal stem cells, and loaded into the core (alginate) with the sheath made from carboxymethyl cellulose and alginate lyase. This design allows controlled scaffold degradation and efficient EVs release.
05:52
Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
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Cited by 21 •
2019
Presented here is a simple-to-use, core/shell, three-dimensional bioprinting set-up for one-step fabrication of hollow scaffolds, suitable for tissue engineering of vascular and other tubular structures.
02:10
The Nucleosome Core Particle
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2020
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins. The paradox Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
04:33
Decellularized Porcine Esophageal Scaffold Preparation: A Technique to Generate Acellular Scaffold from a Pig Esophagus
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2023
In this video, we demonstrate the preparation of a decellularized pig esophagus scaffold, with its biochemical architecture and composition preserved, for tissue engineering applications.
09:32
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
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Cited by 5 •
2015
Here, we present a protocol to fabricate electrospun nanofiber scaffolds with gradated organization of fibers and explore their applications in regulating cell morphology/orientation. Gradients with regard to physical and chemical properties of the nanofiber scaffolds offer a wide variety of applications in the biomedical field.
FAQs
Compartmentalization assigns different tasks to the core and sheath instead of requiring one material region to perform every function. The core can support cells, therapeutic agents, or mechanical demands, while the surrounding layer protects it or regulates transport. This separation allows structural support, biological signaling, and delivery behavior to be adjusted within the same construct.
The sheath can regulate how substances move into or out of the inner region and can provide protection for its contents. By controlling access to the core, it supports localized delivery and controlled release of therapeutic agents. Its surrounding position also creates an opportunity to influence biochemical signaling while preserving a distinct internal environment.
Using different polymers or biomaterials for the concentric regions allows each compartment to contribute distinct structural or biological properties. The core material may be selected for cell support, therapeutic-agent incorporation, or load-bearing needs, while the sheath can be tailored for protection or transport regulation. This combination creates tunable mechanical properties and function-specific architecture.
Coaxial processing helps arrange different polymers or biomaterials concentrically during fabrication, preserving a defined core and surrounding sheath. Maintaining this organization is important because the scaffold’s performance depends on keeping structural support, transport regulation, and biological functions in their intended regions. The resulting architecture enables one construct to provide complementary functions without eliminating compartment-specific behavior.
Design should begin by identifying whether the construct must support cells, carry therapeutic agents, bear loads, regulate transport, or provide biochemical signaling. The core and sheath can then be assigned complementary responsibilities, with their materials and architecture adjusted accordingly. This requirement-based approach helps align mechanical behavior, release characteristics, and biological performance with the intended tissue-engineering or delivery use.
They are useful when a regenerative construct must combine cell support with controlled biochemical or structural functions. The core can provide an environment for cells or agents, while the sheath helps regulate exposure and protect the internal compartment. This arrangement may support localized signaling and guide tissue formation, making the approach relevant to tissue engineering and regenerative medicine.
For drug delivery, therapeutic agents can be incorporated into the core while the sheath regulates their release and helps localize the construct’s activity. This design separates agent loading from transport control, allowing the scaffold to provide a more organized delivery environment than a uniform material architecture. The same principles also support localized biochemical signaling in engineered tissues.