T2 Star Imaging
T2 Star Imaging - Related Videos
05:30
Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
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Cited by 1 •
2023
We present a standardized protocol for the quantification of T2* relaxation times of tumors using external software. Multi-echo gradient echo images are acquired and fed into the software to create tumor T2* maps and measure tumor T2* relaxation times.
08:59
High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping
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2024
Here, we show the imaging protocol for observing biomolecular interactions with photothermal off-resonance tapping (PORT), where we optimized imaging parameters, identified system limits, and investigated potential improvements in imaging three-point-star DNA motif assembly.
09:04
In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
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Cited by 7 •
2017
We describe a mouse model of experimental cerebral malaria and show how inflammatory and microvascular pathology can be tracked in vivo using magnetic resonance imaging.
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Cited by 17 •
2017
A protocol for stroke onset time estimation in a rat model of stroke exploiting quantitative magnetic resonance imaging (qMRI) parameters is described. The procedure exploits diffusion MRI for delineation of the acute stroke lesion and quantitative T1 and T2 (qT1 and qT2) relaxation times for timing of stroke.
06:56
Particles without a Box: Brush-first Synthesis of Photodegradable PEG Star Polymers under Ambient Conditions
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Cited by 17 •
2013
Poly(ethylene glycol) (PEG) brush-arm star polymers (BASPs) with narrow mass distributions and tunable nanoscopic sizes are synthesized in via ring opening metathesis polymerization (ROMP) of a PEG-norbornene macromonomer followed by transfer of portions of the resulting living brush initiator to vials containing varied amounts of a rigid, photo-cleavable bis-norbornene crosslinker.
FAQs
Signal decay reflects two processes occurring after radiofrequency excitation: irreversible T2 relaxation and additional loss of phase coherence caused by local magnetic-field variations. Tissue with stronger microscopic susceptibility differences develops greater dephasing, so its signal decreases more rapidly. This relationship allows T2* measurements to reveal composition-related differences and field disturbances within biological tissue.
T2* includes both irreversible T2 relaxation and extra dephasing produced by microscopic magnetic-field inhomogeneities. A conventional T2-related measurement does not represent this combined effect in the same way. Consequently, T2* is especially sensitive to susceptibility-related changes, making it useful when iron-containing compounds, blood oxygenation, hemorrhage, or vascular alterations influence local magnetic fields.
Susceptibility differences alter the magnetic field experienced by nearby spins. Those spins then lose phase coherence at different rates, producing localized signal loss rather than uniform decay across the tissue. Because the strength of this effect varies with tissue composition and vascular conditions, the resulting contrast can connect microscopic or molecular changes with broader patterns of tissue function.
T2* contrast provides sensitivity to blood oxygenation, allowing blood-oxygen-level-dependent functional MRI to detect changes associated with tissue activity. The method translates oxygenation-related magnetic-field effects into differences in signal decay. In biology, this supports investigations that relate changing vascular or oxygenation states to functional behavior in tissue.
T2* measurements can identify signal changes associated with iron-containing compounds and hemorrhage because these conditions influence local magnetic susceptibility and therefore spin dephasing. The resulting maps help researchers assess where such magnetic-field disturbances occur within tissue. This information supports the study of composition changes and disease-related alterations without treating signal loss as a nonspecific finding.
By mapping susceptibility-sensitive signal loss, T2* imaging provides information about vascular structure and blood oxygenation alongside tissue composition. Researchers can compare these patterns with biological function to examine how cellular or molecular properties relate to tissue organization. The same approach also helps characterize alterations associated with hemorrhage or other disease-related changes in vascular tissue.