Personalized Tms Therapy
Personalized Tms Therapy - Related Videos
14:35
Using TMS to Measure Motor Excitability During Action Observation
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique that involves passing current through an insulated coil placed against the scalp. A brief magnetic field is created by current in the coil, and because of the physical process of induction, this leads to a current in the nearby neural tissue. Depending on the duration, frequency, and magnitude of these magnetic...
02:50
Combination Therapies and Personalized Medicine
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2021
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment. The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:50
Combination Therapies and Personalized Medicine
0 Views •
2023
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment. The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
12:38
State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior
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Cited by 4 •
2010
In this article, we examine the effects of visually relevant state dependency on TMS induced motive phosphenic presentations.
13:18
Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Treatment-Resistant Depression
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Cited by 1 •
2026
This protocol describes the workflow of robotically delivered fMRI-guided personalized transcranial magnetic stimulation therapy for treatment-resistant depression. Clinical implementation using this protocol is feasible, and open-label results support the real-world effectiveness of this approach.
FAQs
Personalization begins by aligning stimulation with patient-specific anatomy and neural activity rather than relying on a uniform cortical target. These measurements help identify where stimulation may best engage circuits related to the person’s symptoms. The resulting target can more closely match individual brain organization, supporting precise circuit modulation and potentially more informed treatment selection.
Location, frequency, intensity, and timing are the main adjustable features described for Personalized Tms Therapy. Location determines which cortical region is addressed, while frequency and intensity define the delivered stimulation pattern. Timing can also be modified according to patient-specific measurements and observed outcomes, allowing the treatment plan to evolve as new information becomes available.
The approach connects stimulation with brain circuits involved in a patient’s condition rather than treating symptoms as independent of neural organization. In neuroscience, this circuit-focused perspective helps investigators examine how targeted stimulation may produce clinical effects. It also provides a framework for relating changes in stimulation settings to changes in symptoms and treatment response.
Personalized TMS therapy may reduce variability between patients because the target and stimulation settings can reflect differences in anatomy, neural activity, symptoms, and response. This matters when the same protocol does not affect every person in the same way. Incorporating ongoing outcomes allows clinicians to refine treatment choices instead of treating the initial plan as fixed.
Clinicians can combine anatomical information, measures of neural activity, symptom profiles, and treatment response when planning the intervention. Anatomy helps guide location, neural activity informs circuit targeting, symptoms establish clinical relevance, and response shows whether adjustments may be warranted. Together, these inputs create a patient-specific basis for selecting and refining stimulation.
After an initial plan is selected, clinicians can adjust location, frequency, intensity, or timing in relation to patient-specific measurements and observed outcomes. This makes treatment an iterative process rather than a single fixed prescription. Tracking response links the stimulation delivered at each stage with the person’s symptoms and helps guide subsequent treatment selection.
Depression is one stated application, and the approach also relates to other neuropsychiatric disorders. Its value extends beyond symptom treatment because individualized stimulation can help researchers investigate how particular brain circuits contribute to these conditions. Relating patient-specific stimulation plans to symptoms and response may clarify why clinical effects differ across people.
Within neuroscience, Personalized Tms Therapy connects noninvasive stimulation, brain measurements, and clinical outcomes in one framework. This integration supports more precise investigation of cortical targets and circuits associated with symptoms. It may help clarify how stimulation produces clinical effects by relating the selected target and settings to the individual’s treatment response.