Dry Cough Absence
Dry Cough Absence - Related Videos
09:30
Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
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This study established cough and sneeze models in mice by applying specific stimuli to the trachea and nasal cavity, and developed an audio-based method to distinguish between mouse coughs and sneezes by analyzing differences in their acoustic signals.
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Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact
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In multicellular organisms, secreted soluble factors elicit responses from different cell types as a result of paracrine signaling. Insert co-culture systems offer a simple way to assess the changes mediated by secreted soluble factors in the absence of cell-cell contact.
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Dry Friction
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2023
Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible. To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
06:53
Cell Fractionation of U937 Cells in the Absence of High-speed Centrifugation
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Cited by 4 •
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Here, we present a protocol to isolate the plasma membrane, cytoplasm and mitochondria of U937 cells without the use of high-speed centrifugation. This technique can be used to purify subcellular fractions for subsequent examination of protein localization via immunoblotting.
04:33
Methods for Detecting Cough and Airway Inflammation in Mice
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Cited by 1 •
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Here, we describe the measurement of cough using a noninvasive and real-time whole-body plethysmography (WBP) system and the normative procedures for harvesting tissue samples of mice and introduce some methods to assess airway inflammation.
FAQs
In pharmacologic observation, it suggests that airway sensory pathways and the cough reflex are not being activated strongly enough to produce persistent coughing without sputum. This is a finding about symptom expression, not a mechanism-specific diagnosis. It therefore requires interpretation alongside other clinical findings when evaluating a drug.
Because the finding alone does not identify its cause or explain the status of other respiratory processes. A medication may be recorded as not associated with dry cough, yet that observation by itself cannot establish an overall respiratory safety profile. Researchers should compare it with additional clinical findings and treatment outcomes.
The observation is narrower than a statement that a treatment has no cough-related effect. It concerns persistent coughing without mucus or sputum, whereas the available finding does not establish what happens with other respiratory symptoms. In pharmacology, keeping those observations separate prevents a single symptom record from being overinterpreted.
Researchers can document whether nonproductive coughing is observed while assessing medication tolerability, monitoring respiratory symptoms, or comparing treatment effects. The record should be interpreted with other clinical findings rather than used alone. This approach preserves the distinction between a symptom observation and a conclusion about the medication’s complete respiratory profile.
It is useful when investigators are examining whether a medication is associated with cough-related adverse effects. Recording its absence provides a comparison point for respiratory symptom monitoring and treatment effects. The result can contribute to a broader safety assessment, but it remains one observation rather than a standalone measure of tolerability.
It can help researchers compare whether cough-related symptoms are observed under different medication effects. A lack of the symptom may support a respiratory safety profile that does not include persistent dry coughing, but the comparison is meaningful only when considered with other clinical findings. It does not by itself identify why coughing is absent.