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Immunology and Infection

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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Article DOI: 10.3791/2532-v • 09:58 min • February 14th, 2011
February 14th, 2011 •
1, 1, 1
1Department of Microbiology and Immunology, Albert Einstein College of Medicine

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C57BL/6 mice have been used to study Hc pathogenesis and provide the best model. We are exploring the potential benefits of humoral immunity against this fungus and generated several mAbs [to histone H2B and a heat shock protein 60kDa] that we tested for their protective efficacy after intraperitoneal administration.

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Passive Administration Monoclonal Antibodies H. Capsulatum Fungal Pathogens Histoplasmosis Antibody Therapy Virulence Factors MAbs Generation Solid Phase ELISA System Splenocytes Fusion C57BL/6 Mice Infection Assessment Mortality As An Endpoint Colony Forming Units (CFU) Survival Studies Intervention Efficacy Vaccine Efficacy Virulence Testing
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