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Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Article DOI: 10.3791/50403-v • 06:33 min • July 29th, 2013
July 29th, 2013 •
1,2, 2, 2
1Department of Radiation Oncology, University of Kansas School of Medicine, 2Department of Radiology, University of Texas Health Science Center at San Antonio

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This paper describes in-house procedures of constructing a preclinical multimodality phantom made of tissue-mimicking (TM) materials for quality assurance (QA) of tumor size measurement in animal imaging modalities such as ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI).

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Preclinical Multimodality Phantom Tissue-mimicking Materials Quality Assurance Tumor Size Measurement World Health Organization (WHO) Response Evaluation Criteria In Solid Tumors (RECIST) Radiologic Assessment Anti-tumor Drug Therapy Two-dimensions One-dimension Reproducible Imaging Biomarker United States Food And Drug Administration (FDA) Accuracy Robust Quality Assurance (QA) Procedures QA Phantom Ultrasound (US) Computed Tomography (CT) Magnetic Resonance Imaging (MRI) Gammex US Commercial Phantom Target Lesions Silicone Molds Casting Tumor-simulating Test Objects
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