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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Article DOI: 10.3791/50668-v • 14:20 min • June 13th, 2014
June 13th, 2014 •
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
1Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center

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An example of a nano drug based on polymalic acid is presented towards the rational design of personalized medicine that is applicable to cancer. It describes the synthesis of a nano drug to treat Her2-positive human breast cancer in a nude mouse.

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Polymalic Acid-based Nano Biopolymers Targeting Tumor Markers Personalized Medicine Tumors Grade Morphology Molecular Profiling Silencing Malignancy Associated Genes Nano Drugs Antisense Oligonucleotides Genes Silencing Treatment Toxicity Immune Response Nano Medicine Biodegradable Non-toxic Non-immunogenic Controlled Chemical Ligation Tumor Targeting Molecules Synthesis Treatment Her2-positive Breast Cancer Experimental Mouse Model
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