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Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain

Article DOI: 10.3791/51466-v • 09:14 min • May 14th, 2014
May 14th, 2014 •
1,2, 3, 1, 1, 4
1University of Tennessee Health Science Center, 2Semmes-Murphey Clinic, 3University of Arkansas for Medical Sciences, 4Restorative Neurosciences Foundation

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Convection-enhanced delivery (CED) has been proposed as a treatment option for a wide range of neurological diseases. In order to prepare health care professionals for adoption of CED, accessible training models are needed. We describe the use of agarose gel as such a model of the human brain for testing, research, and training.

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Convection-enhanced Delivery CED Neuroinfusion Catheter Positive Pressure Bulk Flow Real-time MRI Guided CED Agarose Gel Model Brain Phantom Distribution Fraction Vd/Vi Infusion Analysis Neurological Disease Treatment
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