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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Article DOI: 10.3791/51807-v • 10:26 min • August 18th, 2014
August 18th, 2014 •
1, 2, 2, 1,2
1Department of Medicine, Renal division, University of Pittsburgh School of Medicine, 2Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine

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This manuscript presents a simple, yet powerful, in vitro method for evaluating smooth muscle contractility in response to pharmacological agents or nerve stimulation. Main applications are drug screening and understanding tissue physiology, pharmacology, and pathology.

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Bladder Smooth Muscle Strip Contractility Lower Urinary Tract Pharmacology In Vitro Method Smooth Muscle Contractility Physiological Properties Pharmacological Properties Pathology-induced Changes Bladder Function In Vivo Experiments Surgical Manipulations Pharmacological Manipulations Stability Of Preparations Survival Of Preparations Human Tissue Expensive Chemicals Bladder Component Properties Healthy Conditions Pathological Conditions Krebs Solution Contraction Force Measurement Isometric Tension Transducer Fixed Rod Attachment Compound Stimulation Electric Field Stimulation Electrodes Spontaneous Smooth Muscle Contractility Evaluation Developmental Changes Experimental Spinal Cord Injury Evaluation Neurotransmission Properties
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