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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Article DOI: 10.3791/52105-v • 11:57 min • February 23rd, 2015
February 23rd, 2015 •
1, 1, 1, 1, 1,2,3
1Department of Genetics and Development, Toronto Western Research Institute and Spinal Program, University Health Network, Krembil Neuroscience Centre, 2Department of Surgery, University of Toronto, 3Institute of Medical Sciences, University of Toronto

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résumé
Automatic Translation

Treating cervical spinal cord injury with both self-assembling peptides (SAP) and neural precursor cells (NPC), together with growth factors, is a promising approach to promote regeneration and recovery. A contusion/compression aneurysm clip rat model of cervical SCI and combined treatment involving SAP injection and NPC transplantation is established.

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Neural Precursor Cells Self-assembling Peptides Cervical Spinal Cord Injury Neurological Impairment Secondary Mechanisms Inflammation Apoptosis Demyelination Tissue Scarring Intramedullary Cavities Cell Transplantation Regeneration Contusion/compression Model Aneurysm Clip Therapeutic Target Complete Transection Ruptures Of The Cord Weight Drop Model Dorsum Columns Circumferential Compression Clip Closing Force Injury Severity Ring Spring Synthetic Self-assembling Peptides (SAP) Nanofibers
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