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Biochemistry

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JoVE Journal Biochemistry
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Article DOI: 10.3791/54750-v • 12:02 min • November 2nd, 2016
November 2nd, 2016 •
1, 2, 1
1Department of Chemistry, Durham University, 2School of Medicine, Pharmacy and Health, Durham University

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résumé
Automatic Translation

A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

Tags

Synthesis Peptoids Lysine-type Monomers Arginine-type Monomers Anti-leishmanial Activity Neglected Tropical Disease Cutaneous Leishmaniasis Therapeutics Cationic Functionality Biological Activities Mammalian Form Of The Parasite Insect Stage Leishmania Mexicana Synthesis Protocol Dimethylformamide Fmoc-protected Rink Amide Resin
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