In Vitro et In Vivo la détection des Mitophagy dans les cellules humaines, C. Eleganset la souris

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Cité par 33

08:40 min

22 novembre 2017

10.3791/56301-v

22 novembre 2017

17.5K vues

Evandro F. Fang¹^,⁶ , Konstantinos Palikaras² , Nuo Sun³ , Elayne M. Fivenson¹ , Ryan D. Spangler⁴ , Jesse S. Kerr¹ , Stephanie A. Cordonnier¹ , Yujun Hou¹ , Eszter Dombi⁵ , Henok Kassahun⁶ , Nektarios Tavernarakis²^,⁷ , Joanna Poulton⁵ , Hilde Nilsen⁶ , Vilhelm A. Bohr¹^,⁸

¹Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, ²Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, ³Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, ⁴Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, ⁵Nuffield Department of Obstetrics and Gynaecology, University of Oxford, ⁶Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, ⁷Department of Basic Sciences, Faculty of Medicine, University of Crete, ⁸Danish Center for Healthy Aging, University of Copenhagen

Mitophagy, le processus de compensation endommagée mitochondries, est nécessaire au maintien de l’homéostasie et de la santé mitochondriale. Cet article présente certaines de la mitophagy dernière méthodes de détection dans les cellules humaines, Caenorhabditis eleganset la souris.