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JoVE Journal Developmental Biology
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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Article DOI: 10.3791/58379-v • 08:20 min • October 2nd, 2018
October 2nd, 2018 •
1, 1, 1,2, 1,3, 1, 1,4, 1,4,5
1Department of Pediatrics, Johns Hopkins University School of Medicine, 2Department of Health, Beijing Military General Hospital, 3Southern Medical University, 4Department of Molecular and Cellular Physiology, Johns Hopkins University School of Medicine, 5Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine

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We describe the development of a lean PCOS-like mouse model with dihydrotestosterone pellet to study the pathophysiology of PCOS and the offspring from these PCOS-like dams.

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Hyperandrogenic Mouse Model Polycystic Ovary Syndrome (PCOS) Endocrinology Hormone Release DHT Pellet Preparation Silicone Tubing Medical Adhesive Silicone Air Bubbles Personal Protective Equipment DHT Powder Experimental Depth Control Pellets Mouse Model Generation
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