Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images Conve

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Cité par 31

08:52 min

23 mai 2019

10.3791/59232-v

23 mai 2019

6.6K vues

Karam Khateeb¹^,² , Devon J. Griggs²^,³ , Philip N. Sabes⁴ , Azadeh Yazdan-Shahmorad¹^,²^,³^,⁴

¹Departments of Bioengineering, University of Washington, ²Washington National Primate Research Center, ³Department of Electrical and Computer Engineering, University of Washington, ⁴Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco

Ici, nous démontrons la résonance magnétique (MR)-guidée convection a augmenté la livraison (CED) des vecteurs viraux dans le cortex comme approche efficace et simplifiée pour réaliser l'expression optogénétique à travers de grandes zones corticales dans le cerveau macaque.