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Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat
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Thoracic Spinal Cord Hemisection Surgery and Open-Field Locomotor Assessment in the Rat

Article DOI: 10.3791/59738-v • 06:44 min • June 26th, 2019
June 26th, 2019 •
1,2, 1,2,3
1Department of Neurosciences, Faculté de Médecine, Université de Montréal, 2Hôpital du Sacré-Cœur de Montréal, 3Groupe de Recherche sur le Système Nerveux Central (GRSNC), Université de Montréal

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résumé
Automatic Translation

The rat thoracic spinal hemisection is a valuable and reproducible model of unilateral spinal cord injury to investigate the neural mechanisms of locomotor recovery and treatment efficacy. This article includes a detailed step-by-step guide to perform the hemisection procedure and to assess locomotor performance in an open-field arena.

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Thoracic Spinal Cord Hemisection Surgery Open-field Locomotor Assessment Locomotor Deficits Behavioral Phenotypes Anesthetized Adult Rat Incision Paravertebral Muscles Spinous Processes Vertebral Lamina Stereo Microscope Facets Dorsal Connective Tissue Bone Trimmers Scalpel Hemostatic Forceps
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