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Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Article DOI: 10.3791/60108-v • 12:58 min • September 12th, 2019
September 12th, 2019 •
1, 1,2, 1, 1, 1,3
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2Institute of Biotechnology, Life Sciences Center, Vilnius University, 3Cavendish Laboratory, Department of Physics, University of Cambridge

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résumé
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We describe the application of infrared nanospectroscopy and high-resolution atomic force microscopy to visualize the process of protein self-assembly into oligomeric aggregates and amyloid fibrils, which is closely associated with the onset and development of a wide range of human neurodegenerative disorders.

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Atomic Force Microscopy Infrared Nanospectroscopy Protein Aggregates Biomolecular Processes Morphological Resolution Chemical Resolution Structural Resolution Single Molecule Methods Protein Aggregation Human Disease Pharmacological Interventions Biomaterials Drug Delivery AFM Parameters High Resolution Imaging Fibrillar Aggregates
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