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A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Journal JoVE
Médecine
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Journal JoVE Médecine
A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
DOI:

06:36 min

November 28, 2019

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Chapitres

  • 00:05Titre
  • 00:40Detrusor-Free Bladder Preparation Dissection
  • 02:41Denuded Bladder Preparation Filling and Mediator Detection
  • 03:40Results: Representative Denuded Murine Bladder Preparation Assessment
  • 05:44Conclusion

Summary

Traduction automatique

The detrusor-free bladder model enables direct access to the suburothelium to study local mechanisms for regulation of biologically active mediator availability in suburothelium/lamina propria during storage and voiding of urine. The preparation closely resembles filling of an intact bladder and allows pressure-volume studies to be performed without systemic influences.

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