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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Article DOI: 10.3791/60825-v • 11:13 min • March 12th, 2020
March 12th, 2020 •
1, 1, 2, 1
1Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), 2Center for Natural and Human Sciences, Federal University of ABC (UFABC)

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résumé
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A mass spectrometry-guided genome mining protocol is established and described here. It is based on genome sequence information and LC-MS/MS analysis and aims to facilitate identification of molecules from complex microbial and plant extracts.

Tags

Mass Spectrometry Genome Mining Natural Products Whole Genome Sequencing Molecular Networking Chemical Restructure Signatures Active Molecules Discovery Rate Versatile Method Chemotypes Biosynthetic Clusters Bioinformatics Links Metabolic Extracts Streptomyces Species
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