Implantation et contrôle de systèmes sans fil et sans batterie pour l’interfaçage des nerfs périphériques

9.3K vues

Cité par 4

07:13 min

20 octobre 2021

10.3791/63085-v

20 octobre 2021

9.3K vues

Hongkai Wang¹^,² , Dom D’Andrea¹ , Yeon Sik Choi³^,⁴ , Yasmine Bouricha¹ , Grace Wickerson³^,⁴ , Hak-Young Ahn³ , Hexia Guo³^,⁴ , Yonggang Huang³^,⁴^,⁵^,⁶ , Milap S. Sandhu⁷ , Sumanas W. Jordan⁸ , John A. Rogers³^,⁴^,⁶^,⁹^,¹⁰^,¹¹^,¹² , Colin K. Franz¹^,³^,¹³

¹Laboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ²Northwestern University Interdepartmental Neuroscience Program, ³Center for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University, ⁴Department of Materials Science and Engineering, Northwestern University, ⁵Department of Civil and Environmental Engineering, Northwestern University, ⁶Department of Mechanical Engineering, Northwestern University, ⁷Arms and Hands Lab, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ⁸Division of Plastic and Reconstructive Surgery, Biologics, Shirley Ryan AbilityLab, Northwestern University, ⁹Department of Biomedical Engineering, Northwestern University, ¹⁰Department of Neurological Surgery, Northwestern University, ¹¹Department of Chemistry, Northwestern University, ¹²Department of Electrical and Computer Engineering, Northwestern University, ¹³The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine

Il s’agit d’un protocole pour l’implantation chirurgicale et l’exploitation d’une interface alimentée sans fil pour les nerfs périphériques. Nous démontrons l’utilité de cette approche à l’aide d’exemples de stimulateurs nerveux placés sur le nerf sciatique ou phrénique du rat.

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Interface nerveuse périphérique

Stimulation nerveuse sans fil

Implant sans batterie

Modèle du nerf sciatique

Modèle du nerf phrénique

Stimulation électrique

Potentiels d'action musculaires composés

Régénération nerveuse

Transfert d'énergie inductif

Analyse électromyographique

Chapters in this video

0:00

Introduction

0:58

Surgical Procedure for Implantation of a Wireless, Battery‐Free Peripheral Nerve Interface on the Right Sciatic Nerve of the Rat for Electrical Stimulation

3:07

Surgical Procedure for the Implantation of Wireless Stimulators on the Left Phrenic Nerve of the Rat

4:46

Wireless Delivery of Therapeutic Electrical Stimulation

5:29

Results: Nerve Conduction Studies, EMG Recording, and Nerve Regeneration in the Sciatic Nerve Injury Model

6:42

Conclusion