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Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Article DOI: 10.3791/63958-v • 07:47 min • August 31st, 2022
August 31st, 2022 •
*1,2, *3, 2, 1, 4, 1,5, 3
1Department of Diagnostic Radiology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, 2Department of Oncology, MRC Oxford Institute for Radiation Oncology, University of Oxford, 3Department of Surgery, School of Clinical Medicine, HKU-SZH & LKS Faculty of Medicine, The University of Hong Kong, 4Department of Biomedical Engineering, The Chinese University of Hong Kong, 5Department of Diagnostic and Interventional Radiology, Kwong Wah Hospital
* These authors contributed equally

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Here, we present a protocol to create orthotopic hepatocellular carcinoma xenografts with and without hepatic artery ligation and perform non-invasive positron emission tomography (PET) imaging of tumor hypoxia using [18F]Fluoromisonidazole ([18F]FMISO) and [18F]Fluorodeoxyglucose ([18F]FDG).

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Non-invasive PET/MR Imaging Orthotopic Mouse Model Hepatocellular Carcinoma Tumor Hypoxia HCC Biology Translational Research Real-time Monitoring Molecular Changes Tumor Aggressiveness Response To Treatment Intraabdominal Surgery Animal Care Small Animals Sterilize Dorsal Region Anesthetized Mouse Injection Needle Cell Suspension Subcutaneous Plane Syringe Contents Discharge Euthanizing Subcutaneous Tumor-bearing Mouse Incision Scalpel Blade Excise Tumor Block
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