Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Isaac N. Gomez; Serena R. Orsinger; Hyosub E. Kim; Ian Greenhouse

doi:10.3791/64238

Évaluation de l’excitabilité corticospinale au cours d’un comportement d’atteinte d’un objectif

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Évaluation de l’excitabilité corticospinale au cours d’un comportement d’atteinte d’un objectif

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05:05 min

December 2, 2022

DOI: 10.3791/64238-v

Isaac N. Gomez¹, Serena R. Orsinger¹, Hyosub E. Kim², Ian Greenhouse¹

¹Department of Human Physiology,University of Oregon, ²Department of Physical Therapy/Psychological & Brain Sciences,University of Delaware

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Overview

This study presents an innovative method for assessing corticospinal excitability during reaching tasks by combining transcranial magnetic stimulation (TMS) with a behavioral reaching paradigm. The approach is significant as it enhances existing methodologies through a streamlined process that is openly available and adaptable for clinical use.

Key Study Components

Area of Science

Neuroscience
Motor control
Transcranial magnetic stimulation

Background

Reaching is a fundamental skill for interacting with the environment.
Previous studies have explored various methodologies to characterize reaching behavior.
Understanding corticospinal excitability is crucial for insights into motor control.

Purpose of Study

To assess corticospinal excitability during reaching task performance.
To provide a flexible and streamlined approach to study motor behavior.
To facilitate research in clinical populations.

Methods Used

The study utilizes a behavioral reaching paradigm.
Transcranial magnetic stimulation is performed in conjunction with electromyography from a single computer setup.
The method offers adaptability in terms of behavioral tasks and TMS parameters.
The device setup includes a graphics tablet and adjustable monitor position.
Subjects are seated comfortably with their knees flexed at 90 degrees.

Main Results

The method provides unique insights into muscle activity and corticospinal excitability during reaching.
Significant advancements in assessment techniques through streamlined methodologies.
Potential extensions to adaptability for various populations in clinical settings.

Conclusions

This study demonstrates a novel approach that facilitates assessment of motor functions and excitability.
The findings emphasize the relevance of TMS in understanding motor behavior.
Contributes to the understanding of neuronal mechanisms involved in reaching tasks.

Frequently Asked Questions

What are the advantages of this method?

The method streamlines existing approaches to assess corticospinal excitability, making it more efficient and versatile for research and clinical applications.

How is the behavioral model implemented?

The behavioral reaching paradigm is integrated with transcranial magnetic stimulation, allowing for real-time assessment during task performance.

What types of data are obtained using this method?

Data on corticospinal excitability and muscle activity during reaching tasks are collected, providing insights into motor control processes.

How can this method be adapted for clinical populations?

The setup is designed to be mobile and flexible, allowing researchers to easily modify parameters for different clinical needs and participant populations.

What are some key considerations when using this method?

It is important to ensure proper positioning of the subject and equipment for accurate results, along with careful calibration of TMS settings.

Does this method allow for insights into plasticity?

Yes, by assessing changes in corticospinal excitability during tasks, the method can provide insights into neural adaptation and plasticity mechanisms.

Atteindre est une compétence fondamentale qui permet aux humains d’interagir avec l’environnement. Plusieurs études ont visé à caractériser le comportement d’atteinte en utilisant une variété de méthodologies. Cet article propose une application open source de la stimulation magnétique transcrânienne pour évaluer l’état d’excitabilité corticospinale chez l’homme lors de l’exécution de la tâche.

Cette méthode combine un paradigme d’atteinte comportementale flexible avec une stimulation magnétique transcrânienne, l’électromyographie à partir d’un seul ordinateur. C’est important parce que cela simplifie les approches existantes. Les principaux avantages de cette technique sont qu’elle est librement disponible et qu’elle offre une flexibilité en termes de tâches comportementales et de paramètres TMS. Cette configuration peut facilement être adaptée pour être utilisée avec des populations cliniques, car elle est polyvalente et mobile. La méthode offre des informations uniques sur l’excitabilité corticospinale et l’activité musculaire lors de l’atteinte comportementale et de l’adaptation motrice. Placez une grande tablette graphique à plat sur un bureau. Utilisez un cadre en aluminium 80-20 réglable pour positionner le moniteur de tâches de six à huit pouces au-dessus de la tablette, parallèlement à l’écran tourné vers le haut. Ensuite, placez le sujet sur une chaise confortable face à la tablette et assurez-vous que les genoux sont fléchis à 90

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