Demarcation Lines

Demarcation lines are visible boundaries that separate healthy, viable tissue from tissue damaged by ischemia, infection, trauma, or necrosis, helping clinicians assess the extent of disease. They develop as injured tissue undergoes inflammation and cellular death while adjacent tissue retains blood flow and the capacity to recover, producing a clinically recognizable transition zone. In medicine, identifying these lines supports examination, wound assessment, and decisions about debridement or amputation, while changes in their position or clarity can indicate disease progression or treatment response. Accurate interpretation, alongside imaging and other clinical findings, improves planning and helps preserve viable tissue whenever possible.

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JoVE Journal - Medicine
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Cited by 30 •

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