Mouse Prostate
Mouse Prostate - Related Videos
02:34
Individual Lobe Extraction from Prostate: A Technique to Harvest Individual Prostate Lobes from Mouse Prostate
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2023
This video describes a technique to harvest individual lobes from the prostate gland of a mouse model. Individual lobes can then be used for histological analysis and cancer research.
03:24
Extracting Prostate from Mouse Urogenital System: A Technique to Separate Prostate Gland from Other Urinary and Genital System Organs in Male Mouse
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2023
In this video, we describe the procedure for the dissection of the urogenital system or UGS from a male mouse model. This UGS is further dissected ex vivo to isolate the prostate gland and study its role in prostate cancer development.
05:07
Intra-prostatic Injection of Cancer Cells: A Technique to Deliver Cancer Cells for Establishing Orthotopic Prostate Cancer Mouse Model
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2023
In this video, we demonstrate the procedure for administering intra-prostatic injection of prostate cancer cells into a mouse model. Orthotopic murine models can be used to study the disease origin and response to treatment therapies in a non-invasive and clinically relevant environment.
04:40
Modeling Prostate Cancer in Genetically-engineered Mouse Models: A CRISPR/Cas9-mediated Localized Gene Editing Technique in Mouse Anterior Prostate Lobe Cells
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2023
This video describes a method for editing specific genes in prostate gland cells using an adenovirus-based delivery system. The approach allows for orthotopic and localized alteration of gene expression utilizing CRISPR technology to develop novel mouse models for prostate cancer.
09:49
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
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Cited by 25 •
2015
We are measuring perigenital mechanical sensitivity and mast cell activation in the prostate of male C57BL/6 mice that underwent an early life stress paradigm – neonatal maternal separation, in order to induce a preclinical model of chronic prostatitis/chronic pelvic pain syndrome.
FAQs
Androgen signaling affects both epithelial and stromal cells, linking hormonal cues to glandular development, secretory activity, and tissue maintenance. Because these cell populations respond within the same organ, researchers can examine how altered hormonal regulation changes coordinated tissue behavior. This makes the mouse prostate useful for connecting molecular signaling events with structural and functional outcomes.
The lobes provide anatomically distinct settings in which glandular development, secretion, and maintenance can be examined. Their coordinated interactions may reveal how regional tissue behavior contributes to normal biology or disease-associated changes. Comparing lobes helps researchers determine whether a molecular or cellular effect is broadly shared or linked to a particular part of the gland.
Epithelial and stromal cells respond to androgen signaling and interact during tissue maintenance and glandular activity. Studying them together allows researchers to assess cell communication rather than viewing each population in isolation. This cellular perspective can clarify how changes at the molecular level become tissue-level alterations relevant to inflammation, benign prostatic hyperplasia, or prostate cancer.
Mouse prostate models allow investigators to relate genetic alterations to changes in molecular regulation, cellular communication, and tissue condition. Comparing these levels helps clarify how an alteration may influence disease progression rather than merely identifying an associated molecular change. Such analysis supports investigation of mechanisms underlying prostate cancer and other pathological changes in a controlled biological model.
Researchers can use these models to examine how an intervention affects molecular features and tissue-level outcomes in the prostate. Evaluating both levels helps determine whether treatment-associated changes correspond to altered disease processes or glandular behavior. This application supports preclinical assessment of therapeutic strategies for conditions including inflammation, benign prostatic hyperplasia, and prostate cancer.
These experiments can connect molecular changes with tissue-level outcomes, including effects on glandular development, secretory activity, and tissue maintenance. That connection provides a broader interpretation than molecular data alone and helps researchers assess how hormonal regulation, cell communication, or genetic alterations influence disease-related biology. The resulting evidence can inform diagnostic and therapeutic strategy development.
Comparative studies help distinguish shared biological principles from effects that depend on a particular lobe, cellular interaction, hormonal condition, or genetic change. This approach can reveal how prostate biology and disease progression vary across experimental contexts. In medicine, such comparisons strengthen interpretation of model findings and help guide the preclinical evaluation of diagnostics and treatments.