Murine Bladder Carcinoma
Murine Bladder Carcinoma - Related Videos
09:07
An Orthotopic Model of Murine Bladder Cancer
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Cited by 24 •
2011
Bladder tumors are established in female mice in a minimally invasive fashion through catheterization, local cauterization, and subsequent adhesion of carcinoma cells to the burn sites.
04:15
Bladder Tumor Organoid Model: A Method for Orthotopic Transplantation of Bladder Organoids into Recipient Murine Bladder
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2023
In this video, we describe the orthotopic transplantation of cultured bladder tumor organoids into the murine bladder to study the role of the organ environment on developing tumors.
08:15
Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
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Cited by 16 •
2014
The established technique to inoculate primary invasive orthotopic bladder cancer xenografts requires laparotomy and mobilization of the bladder. This procedure inflicts significant morbidity on the mice, is technically challenging and time-consuming. We therefore developed a high-precision, percutaneous approach utilizing ultrasound guidance.
06:23
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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Cited by 8 •
2017
This protocol describes the generation of murine orthotopic bladder tumors in female C57BL/6J mice and the monitoring of tumor growth.
04:28
Modeling Orthotopic Bladder Tumor in Mouse Model: A Procedure for Intravesical Administration of Cancer Cells into Murine Bladder
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2023
In this video, we describe the intravesical procedure of delivering cancer cells into the bladder of a mouse model. This procedure helps generate an orthotopic bladder tumor model that can be used to develop therapeutic strategies.
FAQs
Genetic and epigenetic alterations can disrupt cell-cycle regulation, apoptosis, and tissue organization in urothelial cells. Loss of normal growth control allows affected cells to persist and proliferate, while impaired tissue organization can support malignant behavior. Examining these changes helps investigators connect molecular abnormalities with tumor progression and identify biological processes that may be relevant to bladder cancer research.
Cell-cycle regulation limits when cells divide, whereas apoptosis removes cells that are damaged or no longer needed. In murine bladder carcinoma, disruption of both processes can favor the accumulation and continued growth of abnormal urothelial cells. Studying these mechanisms clarifies how tumors develop and provides a basis for evaluating interventions intended to alter malignant growth or survival.
The tumor microenvironment includes cancer cells, stromal tissues, and immune components that interact during tumor development. These relationships can affect tissue organization, disease progression, and how a tumor responds to intervention. Murine bladder carcinoma therefore offers more than a cancer-cell-only system: it enables researchers to examine interactions among malignant cells and surrounding biological compartments within the bladder.
These models allow investigators to examine how tumor cells interact with the immune microenvironment while assessing approaches designed to produce an anticancer response. Such studies can connect immune-related effects with tumor progression and treatment response. This context is valuable because therapeutic activity may depend not only on cancer-cell behavior but also on communication between malignant and immune components.
Researchers use these models to investigate tumor biology, disease progression, biomarker development, and anticancer therapies. A study may focus on how the tumor changes over time, which biological features can serve as biomarkers, or whether an intervention alters treatment response. Together, these applications make the model useful for linking mechanistic findings with medically relevant cancer research questions.
Studies can examine patterns of tumor progression, changes associated with urothelial malignancy, biomarker-related findings, and responses to anticancer treatment. Investigators may also assess effects involving stromal tissues or the immune microenvironment. These outcomes help determine whether a model supports a particular research objective, such as understanding disease biology, comparing therapeutic responses, or studying immune-based approaches.