Duke Immersive Virtual Environment

The Duke Immersive Virtual Environment (DiVE) is a room-sized virtual reality system that surrounds users with computer-generated three-dimensional scenes, enabling controlled study of perception, behavior, and brain function. It works by projecting synchronized stereoscopic images onto surrounding screens while tracking the user’s head or body position, allowing the visual scene to update with natural movement and perspective. In neuroscience, DiVE supports experiments on spatial navigation, sensory integration, learning, and motor responses in realistic yet reproducible environments. By combining experimental control with immersive interaction, it helps researchers connect behavior to neural mechanisms and evaluate how the brain constructs and responds to the surrounding world.

Duke Immersive Virtual Environment - Related Videos

Research

JoVE Journal - Neuroscience
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Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality

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Cited by 25 •

2010

Classical fear conditioning paradigm was adapted for human participants in a fully immersive virtual reality setting. Using a discrimination paradigm, conditioned fear, cue and context memory retention, and extinction was measured with skin conductance response to dynamic virtual snakes and spiders (the conditioned stimuli) in two distinct virtual contexts.

Research

JoVE Journal - Behavior

VR Nature Therapy: Embodiment and Emotional Regulation through Immersive Virtual Environments

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2026

Here, we present a protocol to investigate the effects of immersive 360-degree virtual reality nature exposures on mood and embodiment. Participants experience forest and marine environments in seated and standing postures, with assessments using standardized scales to evaluate therapeutic outcomes for mental health interventions.

Leveraging Virtual Reality for Immersive Segmentation and Analysis of Cryo-Electron Tomography Data

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Cited by 1 •

2025

Cryo-electron tomography (cryo-ET) enables 3D visualization of cellular ultrastructure at nanometer resolution, but manual segmentation remains time-consuming and complex. We present a novel workflow that integrates advanced virtual reality software for segmenting cryo-ET tomograms, showcasing its effectiveness through the segmentation of mitochondria in mammalian cells.

Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment

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Cited by 85 •

2014

Here we describe the experimental procedures involved in two-photon imaging of mouse cortex during behavior in a virtual reality environment.

Research

JoVE Journal - Engineering
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The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

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Cited by 7 •

2022

Virtual reality (VR) is a powerful yet underutilized approach to advance the diagnosis and treatment of neurological disease. The Cleveland Clinic Virtual Reality Shopping platform combines state-of-the-art VR content with an omnidirectional treadmill to quantify instrumental activities of daily living-a proposed prodromal marker of neurological disease.

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