Plasma Metabolism
Plasma Metabolism - Related Videos
07:37
Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
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Cited by 66 •
2017
A high-throughput cold physical plasma treatment protocol of liquids and cells is shown. It involves setting up different feed gas compositions for plasma ignition, measuring the plasma's emission spectra, and the subsequent analysis of liquids and cellular activity after plasma treatment.
08:42
How to Ignite an Atmospheric Pressure Microwave Plasma Torch without Any Additional Igniters
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Cited by 25 •
2015
This movie shows how an atmospheric plasma torch can be ignited by microwaves with no additional igniters and provides a stable and continuous plasma operation suitable for plenty of applications.
06:59
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Cited by 7 •
2016
The goal of this protocol is to present a standard method to perform intravenous glucose tolerance tests (IVGTTs) to assess glycemic control in nonhuman primates and assess their metabolic status from healthy to dysmetabolic.
06:36
Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet
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Cited by 6 •
2020
This protocol is presented to characterize the setup, handling, and application of the COST-Jet for the treatment of diverse surfaces such as solids and liquids.
08:36
An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation
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Cited by 21 •
2016
An experimental setup was created for the helium-operated kHz frequency plasma jet. The setup includes a cage for the plasma power supply and jet and an in-house built reactor to monitor plasma-induced reactive species without the interference of the ambient atmosphere.
FAQs
Hydrolysis and oxidation provide distinct chemical routes for modifying circulating drug molecules. Plasma enzymes or other reactive components can initiate these transformations, changing the original compound into metabolites with different properties. Identifying which route occurs helps explain why a drug’s circulating concentration changes and supports interpretation of the resulting pharmacokinetic profile.
A metabolite may retain activity, lose activity, or become more readily eliminated than the parent compound. These differences can alter the overall therapeutic or toxicological profile observed in plasma. Measuring or interpreting metabolite formation therefore helps determine whether the original drug’s effects may persist, diminish, or change during circulation.
The key distinction is the location where molecular transformation occurs. Plasma metabolism reflects changes taking place in the bloodstream, whereas hepatic or tissue metabolism represents processing outside plasma. Separating these contributions prevents all concentration changes from being attributed to organs or tissues and improves interpretation of pharmacokinetic behavior.
Transformation in plasma can reduce the amount of unchanged drug circulating over time while generating metabolites with different biological and elimination properties. Consequently, plasma metabolism can contribute to the observed concentration profile and duration of exposure. Recognizing this contribution is important when relating measured drug levels to persistence and pharmacological effects.
An assessment examines how circulating compounds change and how those changes relate to pharmacokinetic profiles. It can help distinguish bloodstream transformations from hepatic or tissue processes and identify whether resulting metabolites are active, inactive, or more readily eliminated. This information supports evaluation of drug stability, bioavailability, dosing, and toxicity.
Plasma metabolism provides information about how predictably a compound may persist and whether circulating transformation could alter its activity. Developers can use these findings to consider stability, bioavailability, dosing implications, and potential toxicity. The broader goal is to design compounds with more predictable persistence and therapeutic activity in the bloodstream.