Why does null hypothesis testing matter for MS lesion marker validation?

Null hypothesis testing using 7T MRI-derived lesion markers enables objective differentiation between MS and other neuroinflammatory conditions, supporting robust target validation and reducing false positives in early discovery.

How does independent variable isolation in 7T MRI fit the discovery pipeline?

Isolating imaging variables such as MR contrast type and field strength allows researchers to attribute observed lesion features specifically to MS pathology, strengthening mechanistic insights and informing model selection.

What do quantitative dependent variable measurements from 7T MRI enable?

Quantitative lesion measurements, such as volume and marker prevalence, provide standardized endpoints for comparing disease states and evaluating intervention effects across studies and models.

Why are replication requirements critical for cross-functional imaging studies?

Replication of imaging protocols and outputs ensures reproducibility and comparability across research teams, facilitating cross-functional collaboration and enterprise-wide data integration.

What statistical analysis capabilities are needed before implementing 7T MRI protocols?

Robust statistical tools are required to analyze imaging outputs, validate marker specificity, and support decision-making at key pipeline inflection points, ensuring reliable advancement of neuroinflammatory disease programs.

הדמיית תהודה מגנטית של טרשת נפוצה ב 7.0 טסלה

9.9K צפיות

צוטט 4 פעמים

08:51 דק'

19 בפברואר 2021

10.3791/62142-v

19 בפברואר 2021

9.9K צפיות

Sonia Waiczies^*¹ , Antje Els^*¹ , Joseph Kuchling^*²^,³^,⁴ , Karin Markenroth Bloch⁵ , Anna Pankowska⁶^,⁷ , Helmar Waiczies⁸ , Carl Herrmann¹ , Claudia Chien²^,³ , Carsten Finke⁴^,⁹ , Friedemann Paul²^,³^,⁴ , Thoralf Niendorf¹^,²^,⁸

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, ²Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, ³NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, ⁴Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, ⁵The Swedish National 7T Facility, Lund University Bioimaging Center, Lund University, ⁶Department of Radiography, Medical University of Lublin, ⁷ECOTECH-COMPLEX, Maria Curie-Skłodowska University, ⁸MRI.TOOLS GmbH, ⁹Berlin School of Mind and Brain, Humboldt-Universität zu Berlin

^* These authors contributed equally

כאן, אנו מציגים פרוטוקול לרכישת תמונות תהודה מגנטית (MR) של מוחות של חולי טרשת נפוצה (MS) ב 7.0 טסלה. הפרוטוקול כולל הכנת ההתקנה כולל סלילי תדר רדיו, הליכי ראיון סטנדרטיים עם חולי טרשת נפוצה, מיקום נושא בסורק MR ורכישת נתוני MR.