Hypothermia
Hypothermia - Related Videos
08:22
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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Cited by 1 •
2020
The distinct effects of different degrees of hypothermia on myocardial protection have not been thoroughly evaluated. The goal of the present study was to quantify the levels of cell death following different hypothermia treatments in a human cardiomyocyte-based model, laying the foundation for future in-depth molecular research.
05:00
Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Cited by 6 •
2021
This article describes two methods of whole-body short-duration hypothermia induction in rats. The first, rapid induction method, employs active cooling using fans and ethanol spray for a rapid decrease in temperature. The second method is a gradual cooling method. This is achieved using the combination of isoflurane anesthesia and the reduction of temperature settings on the homeothermic heat mat. This results in a gradual decrease in core body temperature without the use of any external...
12:13
Considerations for Rodent Surgery
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2016
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN The Guide for the Care and Use of Laboratory Animals1 dictates that rodent survival surgery be performed aseptically. Aseptic technique utilizes specific practices that minimize the contamination of the surgical site, including patient preparation, surgeon preparation, sterilization of instruments and other supplies, and the use of a clean and controlled environment. Presurgical planning,...
03:58
Apical Resection Neonatal Mouse Model: A Surgical Procedure to Amputate the Ventricular Apex to Study Regenerative Potential in a Neonate Mouse Heart
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2025
In this video, we demonstrate the procedure to surgically remove the left ventricular apex of a neonatal mouse heart.
01:36
Rabbit Preoperative Preparation, Surgical Procedures, and Postoperative Care
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Preoperative Preparation The initial assessment should include observation of alertness, posture, gait, and grooming behavior, as changes in these parameters may indicate underlying health issues. Body weight should be recorded...
FAQs
The body initially narrows peripheral blood vessels to reduce heat loss and activates shivering to generate warmth. These responses can temporarily support temperature regulation, but they do not continue to compensate indefinitely. As cooling progresses, thermoregulation becomes impaired, so the early protective mechanisms become insufficient and clinical assessment must account for worsening physiological instability.
Cooling increasingly interferes with the systems that maintain normal body function. Neurologic, respiratory, and cardiovascular impairment may emerge as thermoregulation fails and body temperature continues to fall. This multisystem effect explains why hypothermia is potentially life-threatening and why clinicians monitor vital signs rather than relying only on visible shivering or the circumstances of exposure.
Therapeutic cooling is a selected clinical strategy intended to protect tissues, whereas harmful hypothermia reflects uncontrolled or unwanted heat loss. The distinction depends on purpose, control, and monitoring. Because temperature reduction can also disrupt neurologic, respiratory, and cardiovascular function, therapeutic applications require careful observation and should not be treated as equivalent to accidental cooling.
Assessment combines recognition of the clinical context, evaluation of severity, and monitoring of vital signs. Clinicians consider whether cooling is exposure-related or associated with a medical cause, then use the degree of temperature reduction and physiological effects to guide care. This approach helps determine how closely the patient must be monitored and how rewarming should proceed.
Controlled rewarming aims to restore temperature while clinicians continue observing vital signs and the effects of cooling on body systems. Supportive care addresses the associated neurologic, respiratory, and cardiovascular disturbances rather than focusing only on temperature. The required approach is guided by the severity of hypothermia, its cause, and the patient’s physiological response during treatment.
In trauma management and perioperative care, preventing or addressing unwanted temperature reduction is part of protecting overall physiological function. Hypothermia can complicate care because progressive cooling affects multiple organ systems. Clinical teams therefore use recognition, severity grading, vital-sign monitoring, controlled rewarming, and supportive care to manage temperature-related risks in these settings.