Electrolytic Thrombus Induction
Electrolytic Thrombus Induction - Related Videos
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
06:03
Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis
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Cited by 39 •
2011
The electrolytic induction of endothelial activation to the internal surface of the Inferior Vena Cava results in venous type thrombus formation due to endothelial activation and partial blood stasis, two components of Virchow's triad.
05:54
Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation
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2025
This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.
02:52
Electrolytic Cells - Concepts
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2020
Electrochemistry Electrochemistry is a branch of chemistry that describes and measures the relationship between electrical energy and a chemical change. Electrochemical reactions involve the movement of electrons from one species to another. If the reaction is spontaneous, it can result in a generated current. If the reaction is not spontaneous, it can be driven by the application of current. In electrochemistry, the key reaction is the oxidation-reduction reaction, called a redox reaction. The...
08:55
Electrolytic Cells - Student Protocol
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2020
Source: Smaa Koraym at Johns Hopkins University, MD, USA Electrolytic CellsExpand In this experiment, you will be assembling an electrolytic cell to perform electroplating. An electrolytic cell contains an anode and cathode connected by a power source, which drives the nonspontaneous redox reaction in the cell. When the anode material is oxidized, the ions travel to the cathode, where they are reduced and plated. In the case of this experiment, the electrolytic cell contains a copper anode...
FAQs
The localized electrical current acts at the electrode site, producing endothelial injury that initiates thrombus formation. This injury promotes platelet activation and engages coagulation, so clot development reflects interacting vascular and blood-based responses rather than a single isolated event. The resulting model helps researchers examine how these processes evolve at a defined vascular location.
Endothelial injury links the electrical stimulus to the biological events that support clot development. Once the vessel lining is disturbed, platelet activation and coagulation can contribute to thrombus formation. This makes the method useful for studying vascular responses alongside clot formation, rather than measuring platelet or coagulation activity as isolated processes.
Its main experimental advantage is control over where and when thrombus formation occurs. Researchers can apply the regulated electrical stimulus at a selected vascular site and use the timing of induction to standardize experiments. This consistency supports comparisons among thrombus responses, antithrombotic treatments, devices, and mechanisms studied in animal models.
The model allows investigators to examine thrombus development together with platelet activation, coagulation, and vascular responses to localized endothelial injury. Considering these events together can help clarify how a clot forms in a vessel and how interventions influence that process. It therefore supports mechanistic studies relevant to cardiovascular and cerebrovascular disease.
In the experimental workflow, researchers use an animal model, position a small intravascular electrode at the selected vascular site, and deliver a carefully regulated electrical current. The induced response can then be used to study thrombus formation, vascular effects, or treatment responses. Control of the stimulus helps maintain a standardized experimental setting.
Researchers may select this approach when they need a controlled animal model for investigating thrombosis or testing antithrombotic therapies. Its localized and timed induction is also useful for evaluating drugs and devices under comparable conditions. The findings can contribute to research on disease mechanisms and interventions related to cardiovascular and cerebrovascular disorders.
Because thrombus formation can be induced at a controlled location and time, investigators can compare how treatments or devices affect clot development and associated vascular responses. The model provides a standardized setting for evaluating antithrombotic effects rather than relying on an uncontrolled thrombotic event. This supports preclinical investigation of therapies relevant to cardiovascular and cerebrovascular disease.