Orthopedic Implant Infection
Orthopedic Implant Infection - Related Videos
07:02
Animal Model of Implant-Associated Infections in Mice
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2025
The present protocol describes a mouse model employing subcutaneous dorsal implantation to investigate implant-associated infections, enabling comprehensive investigation of pathophysiological mechanisms and supporting the development of diagnostic criteria with targeted therapeutic strategies.
18:40
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
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Cited by 19 •
2014
Combined optical and μCT imaging in a mouse model of orthopaedic implant infection, utilizing a bioluminescent engineered strain of Staphylococcus aureus, provided the capability to noninvasively and longitudinally monitor the dynamics of the bacterial infection, as well as the corresponding inflammatory response and anatomical changes in the bone.
03:12
In Vivo Analysis of Implant-Associated Bacterial Infections Using Zebrafish Embryos
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2025
Source: Zhang, X. et. al., A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection. J. Vis. Exp. (2019)This video demonstrates a zebrafish embryo model for studying infections linked to implanted biomaterials. Injecting Staphylococcus aureus with polystyrene microspheres enhances bacterial survival, confirming the infection-promoting role of implanted materials.
14:31
Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
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Cited by 16 •
2009
There is a need to develop alternative prosthesis attachment due to limb loss attributed to vascular occlusive diseases and trauma. The goal of the work is to introduce an osseointegrated intelligent implant design system to increase skeletal fixation and reduce periprosthetic infection rates for patients needing osseointegrated technology.
10:30
Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
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Cited by 28 •
2016
Culturing human Mesenchymal Stromal Cells (hMSCs) with autologous serum, reduces the risks of rejection by xenogeneic material and other negative effects. It also allows for the recovery of a subset of mesodermal progenitors, which can deliver fresh hMSCs. Embedding hMSCs in an autologous fibrin clot enables easy handling and effective surgical implantation.
FAQs
After microorganisms attach to an implant surface, they can organize into a biofilm: a structured community enclosed in protective material. This organization changes the infection from a freely exposed microbial presence into a surface-associated problem. Because the protective material can limit immune clearance, the implant surface becomes important to persistence and treatment decisions.
Biofilm formation matters because it can reduce antimicrobial penetration as well as immune clearance. Consequently, treatment must account for both the microorganisms and the device-associated environment, rather than focusing only on symptoms. This mechanism helps explain why management may combine targeted antimicrobial therapy with debridement, implant retention or removal, and revision procedures.
The diagnostic challenge is addressed by combining clinical assessment with laboratory testing, imaging, and analysis of tissue or implant-associated samples. These sources provide complementary evidence rather than a single definitive view. Using several forms of assessment can support earlier recognition and help guide subsequent management decisions.
When infection interferes with healing, the surrounding repair process may be compromised, while reduced implant stability can undermine the device's mechanical role. Together, impaired healing and instability can affect patient function, making infection control relevant not only to microbiology but also to recovery and reconstructive planning.
Evaluation begins with clinical assessment and is supplemented by laboratory testing and imaging. Clinicians may also analyze tissue or implant-associated samples, adding direct information from the affected site. Combining these steps helps connect the patient's presentation with microbiological and structural evidence, which is important when planning antimicrobial or surgical management.
Tissue or implant-associated samples can add site-specific evidence to the evaluation. Their analysis complements clinical assessment, laboratory testing, and imaging, helping clinicians assess whether findings are consistent with an implant-related infection. This information can be especially relevant when deciding whether antimicrobial treatment or a surgical intervention is needed.
Management may require a coordinated combination of targeted antimicrobial therapy and surgery. Surgical options can include debridement, retention of the implant, removal of the device, or a revision procedure. The selected strategy must address infection while also considering implant stability, healing, and the patient's functional recovery.
Understanding biofilm formation provides a scientific basis for improving infection prevention, recognizing implant-associated infection earlier, and developing more effective treatment strategies. It connects microbial behavior on device surfaces with clinical outcomes such as impaired healing, instability, and reduced function, making biofilm research relevant to both diagnosis and orthopedic care.