Microdrive Construction
Microdrive Construction - Related Videos
10:44
Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice
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Cited by 30 •
2013
The design and assembly of microdrives for in vivo electrophysiological recordings of brain signals from the mouse is described. By attaching microelectrode bundles to sturdy driveable carriers, these techniques allow for long-term and stable neural recordings. The lightweight design allows for unrestricted behavioral performance by the animal following drive implantation.
10:29
Design and Assembly of an Ultra-light Motorized Microdrive for Chronic Neural Recordings in Small Animals
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Cited by 15 •
2012
The design, fabrication and assembly of an ultra-light motorized microdrive is described. The device provides a cost-effective and easy-to-use solution for chronic recordings of single units in small behaving animals.
13:43
Fabrication of Myogenic Engineered Tissue Constructs
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Cited by 11 •
2009
Here, we demonstrate fabrication of collagen-based, tissue constructs containing skeletal myoblasts. These 3-D engineered constructs may be used to replace or repair tissues in vivo. For our purposes, we have designed these as an atrioventricular electrical conduit for the repair of complete heart block[1].
13:48
Design and Construction of an Urban Runoff Research Facility
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Cited by 6 •
2014
This paper describes the design, construction, and function of a 1,000 m2 facility containing 24 individual 33.6 m2 field plots equipped for measuring total runoff volumes with time and collection of runoff subsamples at selected intervals for quantification of chemical constituents in the runoff water from simulated home lawns.
10:08
Construction and Setup of a Bench-scale Algal Photosynthetic Bioreactor with Temperature, Light, and pH Monitoring for Kinetic Growth Tests
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Cited by 4 •
2017
This paper describes the assembly process and operation of a bench-scale photosynthetic bioreactor that can be used, in conjunction with other methods, to estimate pertinent kinetic growth parameters. This system continuously monitors the pH, light, and temperature using sensors, a data acquisition and control unit, and open-source data acquisition software.
FAQs
A threaded screw, guide cannula, or comparable actuator converts mechanical movement into controlled changes in electrode depth. This arrangement allows the researcher to advance the electrode in measured increments rather than relying on a single fixed position. Precise depth adjustment is important when targeting neural signals across extended experiments and when relating recordings to changing behavioral conditions.
The drive must remain secured to the skull while the electrode is adjusted and electrical signals are collected. Stable attachment helps preserve the intended electrode position and maintain access to neural activity over time. This mechanical stability supports chronic experiments in which researchers compare recordings across sessions instead of treating each measurement as an isolated observation.
An adjustable architecture permits researchers to change recording depth after the device has been installed. That flexibility can help investigate neural activity at different positions, track signals across sessions, and support recordings from more than one brain region. A fixed placement cannot provide the same built-in capacity for controlled repositioning during a chronic study.
Because the drive remains attached to the skull while providing adjustable electrode access, it can support chronic electrophysiology during repeated behavioral sessions. Researchers can examine neuronal firing while an animal is awake and performing tasks, then compare activity with behavior, learning, or other changes observed over time. The design therefore links stable access with longitudinal neural measurement.
Construction centers on matching a compact mechanical frame with an electrode-positioning element, such as a threaded screw or guide cannula, and a means of securing the assembled drive to the skull. The design must preserve controlled electrode advancement while maintaining electrical access. These components determine whether the device can support repeated depth adjustments during extended recordings.
The device is assembled around its mechanical positioning elements, arranged to guide the electrode, and secured so the drive remains stable on the skull. During the experiment, the actuator is used to change electrode depth in controlled increments while neural signals are recorded. This workflow enables repeated measurements across sessions without rebuilding the recording arrangement each time.
Adjustable microdrives can support studies that connect neuronal activity with behavior, learning, and disease-related changes. Their capacity to track neural signals across sessions also helps researchers examine how firing patterns evolve over time. When configured for access to multiple brain regions, they extend comparisons beyond a single neural location within the same broader investigation.