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Intranasal Administration of CNS Therapeutics to Awake Mice
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JoVE Journal Medicina
Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

57,717 Views

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07:15 min

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April 08, 2013

DOI:

10.3791/4440-v

DOI:
10.3791/4440-v

•

07:15 min
April 08, 2013

•

107 Views
, , ,
1Alzheimer’s Research Center at Region’s Hospital,HealthPartners Institute for Education and Research

Summary

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A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic exposure.

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Hanson, L. R., Fine, J. M., Svitak, A. L., Faltesek, K. A. Intranasal Administration of CNS Therapeutics to Awake Mice. J. Vis. Exp. (74), e4440, doi:10.3791/4440 (2013).

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