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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Article DOI: 10.3791/50839-v • 11:37 min • November 29th, 2013
November 29th, 2013 •
1, 1
1Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), University of Heidelberg

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Protein conformation and dynamics are key to understanding the relationship between protein structure and function. Hydrogen exchange coupled with high-resolution mass spectrometry is a versatile method to study the conformational dynamics of proteins as well as characterizing protein-ligand and protein-protein interactions, including contact interfaces and allosteric effects.

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Protein Dynamics Hydrogen Exchange Mass Spectrometry Cellular Processes Protein Functionality Amino Acid Sequence Protein Folding Conformational Changes Functional Cycle HX-MS Structural Information Crystallography Ligand Binding Protein-protein Interactions Enzyme Catalysis Allostery Limited Protein Amount Protein Crystallization
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