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Developmental Biology

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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Article DOI: 10.3791/52567-v • 09:45 min • March 31st, 2015
March 31st, 2015 •
1, 2, 3, 3, 1,3
1Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Center for Individualized Medicine, 2Tufts University School of Medicine, 3Department of Biochemistry and Molecular Biology, Mayo Clinic

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The goal of this study is to demonstrate how the mosaic transgenesis strategy can be used in zebrafish to rapidly and efficiently assess the relative contributions of multiple oncogenes in tumor initiation and progression in vivo.

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Mosaic Zebrafish Transgenesis Functional Genomic Analysis Candidate Cooperative Genes Tumor Pathogenesis Genetic Alterations Oncogenic Drivers Zebrafish As An Animal Model In Vivo Imaging Transgenic Techniques Transgenic Fish Model Cooperation Of Multiple Genes Disease Pathogenesis Mosaic Transient Transgenic Approach
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