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Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury

Article DOI: 10.3791/55753-v • 07:25 min • May 25th, 2017
May 25th, 2017 •
*1, *1,2,3, 4, 3, 5, 6,7, 6, 1,8
1Department of Surgery, Monash University, 2Department of Neurosurgery, Monash University, 3The Ritchie Centre, Hudson Institute of Medical Research, 4Proteobioactives, Pty Ltd, 5Department of Neurosurgery, St Vincent's Hospital, 6Australian Institute for Bioengineering and Nanotechnology, University of Queensland, 7School of Chemical Engineering, University of Queensland, 8Department of Neurosurgery, Monash Health
* These authors contributed equally

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Automatic Translation

Intervertebral disc degeneration is a significant contributor to back pain and a leading cause of disability worldwide. Numerous animal models of intervertebral disc degeneration exist. We demonstrate an ovine model of intervertebral disc degeneration, utilizing a drill bit, which achieves a consistent disc injury and reproducible level of disc degeneration.

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Ovine Lumbar Intervertebral Disc Degeneration Model Lateral Retroperitoneal Approach Drill Bit Intervertebral Disc Injury Degenerative Intervertebral Discs Translational Spinal Research Regenerative Therapies Surgical Injury Anesthetizing Intubating Operating Suite Right Lateral Position Electronic Clippers Shave Region Iliac Bone Contralateral Lumbar Transverse Processes Ipsilateral Lumbar Transverse Processes Landmarks Surgical Incision Site Chlorhexidine And Alcohol Iodine Antiseptic Wash Disinfect Lateral Abdomen Sterile Fenestrated Square Drape
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