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JoVE Journal Medicine
Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening
Murine Model of Wound Healing
Journal (Medicine)
Murine Model of Wound Healing
Models of Bone Metastasis
Journal (Medicine)
Models of Bone Metastasis
 

Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening

Article DOI: 10.3791/56276-v • 09:46 min • February 17th, 2018
February 17th, 2018 •
*1, *1, *1,2,3, 2,3, 1, 1, 1, 1, 1, 1
1Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University, 2Center for Translational Medicine, Nanjing University Medical School, 3Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School
* These authors contributed equally

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This manuscript describes a murine calvarial osteolysis model by exposure to CoCrMo particles, which constitutes an ideal animal model for assessing the interactions between wear particles and various cells in aseptic loosening.

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Murine Calvarial Osteolysis Model CoCrMo Particles Aseptic Loosening Arthroplasty Failure Wear Particle-induced Osteolysis Parthogenesis Of Aseptic Loosening Cobalt Alloy Particle Nanoscale Cobalt Chromium Molybdenum Particles Phosphate Buffer Saline Incision Position Cranial Periosteum Cobalt Alloy Nanoparticles Stock Osteolysis Evaluation Micro-CT
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