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Journal / Chemistry / Automation of a Positron-emission Tomography…
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Chemistry

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Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
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Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production

Article DOI: 10.3791/58428-v • 10:20 min • October 26th, 2018
October 26th, 2018 •
*1, *2,3, 2,4, 1, 2,3, 2,4
1SOFIE, 2Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 3Ahmanson Translational Imaging Division, University of California, Los Angeles (UCLA), 4Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA)
* These authors contributed equally

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Positron-emission tomography (PET) imaging sites that are involved in multiple early clinical research trials need robust and versatile radiotracer manufacturing capabilities. Using the radiotracer [18F]Clofarabine as an example, we illustrate how to automate the synthesis of a radiotracer using a flexible, cassette-based radiosynthesizer and validate the synthesis for clinical use.

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Automation Positron-emission Tomography PET Radiotracer Synthesis Clinical Production Biology Radiochemistry Nuclear Medicine Automate Production Standardize Synthesis Process Repeat Production Improve Reliability Protect Chemist From Radiation Exposure Flexible Radiosynthesizer Multiple Tracers Single Hot Cell Setup Procedure Radionuclide Automated Synthesis Program PET Tracer Fluorine-18 Labeled Clofarabine CFA Precursor Activated Fluoride-18 Intermediate Compound Protecting Groups High-level Steps Required Processes Synthesizer Software
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